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Objective@#To summarize the clinical application of Zhenbao pills (Eerdun-Wurile) in recent years, so as to clarify its clinical efficiency and provide an effective basis for future research.@*Methods@#The clinical application of Zhenbao pills (Eerdun-Wurile) was classified and summarized by consulting the relevant literature.@*Results@#Mongolian medicine Eerdun-Wurile consists of many active ingredients such as <i>Sandalwood Padauk</i>, pearl, <i>Myristica fragrans, Calculus bovis</i>, Bufallo horn concentrated powder, <i>Gardenia jasminoides Ellis, Glycyrrhiza uralensis Fisch, Euphorbia humifusa, Catsia tora Linn, Chingma Abutilon Seed</i>, Resina Liquidambaris, <i>Carthamus tinctorius L, Eugenia caryophyllata Thunb, Cardamoj amomum, Semen Nigellae, Cuminum cyminum L, Piper longum Linn, Lygodium japonicum</i>, crab, medicine terminalia fruit, <i>MeLia toosendan Sieb.etZucc</i>, musk, white sandalwood, <i>Cinnamomum cassia Presl, Aucklandia lappa Decne, Inula helenium L, Amomum tsao-ko Crevostet Lemaire etc</i>. Mongolian medicine Eerdun-Wurile used for treat cardiovascular and cerebrovascular diseases, cerebral infarction, cerebral infarction and ischemic stroke, rheumatic heart disease, coronary heart disease, angina pectoris, rheumatism, kind rheumatism, cervical spondylosis, arthritis, insomnia, high blood pressure, epilepsy, skin diseases, diabetes, eye diseases.@*Conclusion@#Mongolian Medicine Eerdun-Wurile has remarkable curative effect on cardiovascu- lar and cerebrovascular diseases, brain infarction, cerebral infarction, ischemic stroke, diabetic diseases, rheumatism, bone diseases and so on. In this paper, the curative effect of this drug was summarized to provide reference for its clinical application.
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Purpose@#To study the effect of Three roots granule medicine with compound medicines ingredient of Asparagus cohinchinensis, Polygonatum odoratum and Polygonatum sibiricum on acute toxicity test and genotoxicity tests. @*Methods@#In toxicity study of Three roots granule medicine, by acute toxicity test were observed general status of animals, body weight changes, signs of poisoning and death for 14 day and determined the maximum tolerated dose, by Ames test, mouse bone marrow polychromatic erythrocyte micronucleus test and mouse sperm deformity test were determined genotoxicity effect. The data were analyzed through SPSS 19.0.@*Results and Conclusions@#In the result of toxicity study, three roots granule medicine was MTD>15g/kg, no acute toxic activity, did not induce mutagenic effect in Ames test and was negative in mouse bone marrow polychromatic erythrocyte micronucleus test and mouse sperm deformity test. Three roots granule medicine has no acute toxicity effect, no genotoxicity effect and safety. We as regard as in future can continuously study to the other pharmacology study of three roots granule medicine.
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Background@#Trogopterus xanthipes Milne-Edwards (Hadan hailmal) is defecation of Olbo mouse with red and yellow foot in Olbo mouse family. Trogopterus xanthipes Milne-Edwards has bitter and little sweety flavor and cool and sharp quality and it has effects such as to remove hot, to stop pain and to to make urinate etc.@*Purpose@#To summarize chemical compounds, pharmacological effects, clinical usage and ancient source notes of Trogopterus xanthipes Milne-Edwards. @*Method@#Вy analys method to analyzed research articlest and ancient source of Trogopterus xanthipes Milne-Edwards in China Biological Medical Digest Data-base, Chinese Journals Full Text Data-base and ancient sources of Mongolian traditional medicine.@*Results and Conclusions@#Trogopterus xanthipes Milne-Edwards is produced juice from gold, silver, copper, iron, lead and tin on cliff during 4 to 6 months and otherwise Trogopterus xanthipes Milne-Edwards is called defecation of olbo mouse. It has many activity chemical compounds, such as nitrogen compound, volatile compound, Triterpenoid, fatty acid, flavone, and microelement and has many pharmacological effects such as anti gastric ulcer, anti inflammation, anti oxidant, anti cerebral ischemic injury, anti cytotoxicity and to improve immunology. In Mongolian traditional medicine, Trogopterus xanthipes Milne-Edwards mainly used to treat hot disease of stomach, liver and kidney, synovial disease, gout and rheumatism etc with single medicine and compound recipe ingredients of Trogopterus xanthipes Milne-Edwards. In Chinese medicine used to treat disease of digestive system and to stop pain etc.
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Abstract@#To comparatively study the effect of three roots talh(pulvis compositus) medicine and three roots granule medicine in the immune system.@*Materials and Methods@#A total number of 32 healthy Wistar male rats weighing 180-220 grams were taken and equally divided into four groups: healthy group; small dose (0.85g/kg) of three roots talh medicine group(TRSD); high dose (1.7g/kg) of three roots talh medicine group(TRHD) and three roots granule medicine group at dose 1.3g / kg(TRGM). Medicine was given once every day for 42 days. At the end of the study, spleen index and thymus index were calculated and IL-2, IL-6, TNF-α, iNOS, NO levels in blood plasma and spleen using ELISA(Magellan 7.2) was determined and compared with healthy group.@*Result@#There was no statistically significant increase in spleen index and thymus index between the healthy group and medicine groups(p>0.05). In blood plasma, there was no statistically significant difference in IL-2, IL-6, TNF-α, iNOS and NO between healthy and medicine groups (P> 0.05). </br> In spleen, there was significant increased in IL-2 in the high dose three roots talh medicine group in compare with healthy group (p<0.05). Similarly, IL-2, IL-6 and TNF-α was significantly increased in three roots granule medicine group in comapre with healthy group (P<0.05; P<0.05; P>0.001 respectively). There was no significant difference in iNOS and NO between healthy and medicine groups (p>0.05). @*Conclusions@#Three roots talh medicine and three roots granule medicine has active of immune system and three roots granule medicine has more activates the immune system compared to the three roots talh medicine.
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Objective: To explore the effects of Polygonatum odoratum on body based on metabonomics. Methods: The ultra performance liquid chromatography coupled with mass spectrometry (UPLC-MS) and principle component analysis(PCA) and orthogonal partial least squares discriminant analysis(OPLS-DA) were used to evaluate the changes of endogenous substances in rats after intragastric administration of Polygonatum odoratum. Results: Significant differences between the control group and administration group were observed in PCA and OPLS-DA model. Five potential biomarkers between control group and administration group were identified. The relative content of Alpha-Tocotrienol, PC(14:1(9Z)/14:1(9Z)), Stearic acid, Theasapogenol A, Docosahexaenoic acid increased. Conclusion: The biomarkers had many beneficial activities, so the Mongolian medicine Polygonatum odoratum had the function of health care. Key words: Mongolian drug; Polygonatum odoratum; Biomarkers; UPLC-MS