ABSTRACT
Objective To investigate the clinical features and prognostic factors of extrahepatic biliary neuroendocrine neoplasms(EB-NENs).Methods The clinical data and survival of 21 patients with EB-NENs admitted from May 2014 to May 2018 were analyzed retrospectively.Results These 21 EB-NENs patients accounted for 1.6％ (21/1313) of all biliary tract neoplasms treated during the study period.Seven (33.3％) cases had lymph node metastasis.Five (23.8％) suffered from distant metastasis.The follow up time was (4 ～ 46.5) months with median survival time of (23.23 ± 4.17) months.Univariate analysis showed that the risk factors for survival were tumor TNM stage (x2 =9.066,P =0.003),lymph node metastasis(x2 =6.399,P=0.011) and distant metastasis (x2 =9.808,P=0.002).By multivariate analysis,independent risk factors were tumor TNM stage (P =0.008,RR =3.003,95％ CI:1.332 ～ 6.774),lyraph node metastasis (P =0.023,RR =5.382,95 ％ CI:1.261 ～ 22.971) and distant metastasis or not(P =0.007,RR =7.423,95％ CI:1.730 ～ 31.851).Conclusion EB-NENs was a rare malignant tumor with poor prognosis.Tumor TNM stage,lymph node metastasis and distant metastasis were independent prognostic factors for EB-NENs patients.
ABSTRACT
Objective@#To investigate the clinical features and prognostic factors of extrahepatic biliary neuroendocrine neoplasms(EB-NENs).@*Methods@#The clinical data and survival of 21 patients with EB-NENs admitted from May 2014 to May 2018 were analyzed retrospectively.@*Results@#These 21 EB-NENs patients accounted for 1.6% (21/1313) of all biliary tract neoplasms treated during the study period. Seven (33.3%) cases had lymph node metastasis. Five (23.8%) suffered from distant metastasis. The follow up time was (4~46.5) months with median survival time of (23.23 ±4.17) months. Univariate analysis showed that the risk factors for survival were tumor TNM stage (χ2=9.066, P=0.003), lymph node metastasis(χ2=6.399, P=0.011) and distant metastasis (χ2=9.808, P=0.002). By multivariate analysis, independent risk factors were tumor TNM stage(P=0.008, RR=3.003, 95% CI: 1.332~6.774), lymph node metastasis(P=0.023, RR=5.382, 95% CI: 1.261~22.971) and distant metastasis or not(P=0.007, RR=7.423, 95% CI: 1.730~31.851).@*Conclusion@#EB-NENs was a rare malignant tumor with poor prognosis. Tumor TNM stage, lymph node metastasis and distant metastasis were independent prognostic factors for EB-NENs patients.