ABSTRACT
BACKGROUND: The effect of Xianling Gubao Capsule for the elderly female osteoporotic animal models assessed by compression and bending mechanical properties is little reported.OBJECTIVE: To investigate the curative efficacy of Xianling Gubao Capsule, alendronate sodium, calcium carbonate and parathyroid hormone (3-34) for an osteoporotic rat model through compressive and bending tests at the femur.METHODS: The rat models of osteoporosis were established by bilateral ovariectomy, and were then subjected to the treatment of Xianling Gubao Capsule, alendronate sodium, calcium carbonate and parathyroid hormone (3-34),respectively, for 20 weeks. Afterwards, the rats were killed by cutting the abdominal aorta, and then the bilateral femurs were removed to undergo compressive and bending tests.RESULTS AND CONCLUSION: The compressive test: the elastic stress, elastic load, elastic strain, elastic displacement,maximum load, maximum strain, maximum stress, maximum displacement and elastic modulus in the model group were significantly lower than those in the blank control, Xianling Gubao Capsule, alendronate sodium and parathyroid hormone (3-34) groups (P < 0.05). The maximum load, maximum strain, maximum stress, and maximum displacement did not differ significantly between Xianling Gubao Capsule and blank control groups (P > 0.05). All indexes in the compressive and bending tests showed no significant differences between model and calcium carbonate groups (P >0.05). Bending test: the maximum load, maximum stress, maximum strain, maximum bending moment and bending section modulus in the model group were significantly lower than those in the blank control, Xianling Gubao Capsule,alendronate sodium and parathyroid hormone (3-34) groups (P < 0.05). The bending mechanical indexes showed no significant differences between Xianling Gubao Capsule and blank control groups (P > 0.05). To conclude, after compressive and bending tests, Xianling Gubao Capsule, alendronate sodium, and parathyroid hormone (3-34) all restore the mechanical properties of the femur, and Xianling Gubao Capsule obtains a significant curative efficacy.
ABSTRACT
Absrtact: Object vie To observe the INR of AF hyperuricemia patients 'prothrombin time under the situation where both allopurinol and warfarin are used to the treatment of anticoagulation . Methods A total of 240 patients with chronic permanent AF hyperuricemia were collected and then divided randomly into two groups:warfarin treatment group(120 cases), to maintain the original dose warfarin therapy and keep a low-purine diet;and the combined treatment group (120 cases), also in the conventional warfarin antithrombotic therapy and a low-purine diet, on this basis, plus allopurinol 100 mg, three times a day, which last for two weeks .Then observing and examining the change of the two group's INR after the treat-ment. Results The INR of the combined treatment group was obviously higher than the warfarin group ( P<0 .05 ) . Conclusion Allopurinol can increase antithrombotic effect of warfarin .INR should be monitored regularly during the treatment so as to adjust warfarin dosage accordingly .
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate prognosis of stroke and identify the risk factors for stroke recurrence.</p><p><b>METHODS</b>Based on the West China Hospital stroke register database, we conducted a prospective follow-up study of stroke patients to record the potential risk factors of stroke recurrence and investigate stroke recurrence at 1 year. Analysis of the risk factors was performed using a logistic regression model.</p><p><b>RESULTS</b>A total of 1913 stroke consecutive patients admitted to our department were prospectively registered. Of these patients, 599 (31.3%) were identified to have intracerebral hemorrhage (ICH), and 1314 (68.7%) had ischemic stroke. The total recurrence rate at 1 year was 11.2%, and was 10.5% in ischemic patients and 12.7% in ICH patients. Multivariate analysis adjusted for age and gender identified atrial fibrillation, hypertension, hyperlipemia, family history of stroke, and smoking as the risk factors of stroke recurrence at 1 year.</p><p><b>CONCLUSION</b>The 1 year recurrent rate is about 11%, and monitoring the factors of atrial fibrillation, hyperlipemia, hypertension, and smoking may help reduce the recurrence of stroke.</p>