ABSTRACT
BACKGROUND: Plasma cell cheilitis is an unusual benign plasma cell proliferative disease of an unknown etiology that typically presents on the lip. OBJECTIVE: The aim of this study was to investigate the clinicopathological characteristics of 13 cases of plasma cell cheilitis. METHODS: The present study investigated the clinical manifestations, treatment modalities, and outcome of 13 patients diagnosed with plasma cell cheilitis from 2011 to 2016 at Kangdong Sacred Heart Hospital and Hallym University Sacred Heart Hospital. Biopsy specimens of the all cases were evaluated using conventional hematoxylin and eosin staining with kappa and lambda immunoglobulin light chain immunohistochemistry. RESULTS: The age of the patients ranged from 39 to 86 years (mean, 64.7 years), with male predominance. Histopathologically, 61.5% and 38.5% of patients showed band-like and pan dermal plasmacytic infiltrates, respectively. Eosinophilic infiltration was noted in 69.2% of patients. All cases showed both kappa and lambda immunoglobulin light chain reactivities, and kappa predominance was confirmed in 9 patients (69.2%). A majority of the patients was treated with local therapy, such as intralesional steroid injection with topical tacrolimus. Among the 13 patients, plasma cell cheilitis completely resolved, partially resolved, and recurred in 3 (23.1%), 5 (38.5%), and 5 patients (38.5%), respectively. CONCLUSION: Plasma cell cheilitis presented as erosive edematous circumscribed patches or plaques affecting mainly the lower lip of elderly male patients. The majority of histopathology cases showed characteristic plasma cell aggregation on the upper dermis that was immunopositive for immunoglobulin light chain, with kappa predominance.
Subject(s)
Aged , Humans , Male , Biopsy , Cheilitis , Dermis , Eosine Yellowish-(YS) , Eosinophils , Heart , Hematoxylin , Immunoglobulin lambda-Chains , Immunoglobulin Light Chains , Immunohistochemistry , Lip , Plasma Cells , Plasma , TacrolimusABSTRACT
Syringoma is the most common type of benign intraepidermal eccrine sweat gland tumor in Korea, and is usually found in women in their forties. It presents mostly as a localized lesion, preferring the lower eyelid, cheek, or forehead, and rarely invades the vulval area, and in the case of children, vulvar invasion is even more rare. Tranilast is an antihistamine used for atopic dermatitis and asthma, and has recently been used for the treatment of keloid. A few previous studies have reported both localized and generalized forms of syringoma being effectively resolved with tranilast. Herein, we report a rare and interesting case of milium-like syringoma, which manifested on the vulval area of 10-year old girl that was successfully treated with tranilast.
Subject(s)
Child , Female , Humans , Asthma , Cheek , Dermatitis, Atopic , Eyelids , Forehead , Keloid , Korea , Sweat Glands , Syringoma , VulvaABSTRACT
A 4-month-old infant presented with asymptomatic soft nodules on his right forearm, which had developed since birth. On the suspicion of nevus lipomatosus superficialis (NLS), biopsy was performed. Histopathologic findings showed monomorphic polygonal cells with abundant granular cytoplasm. Immunohistochemical stains for CD68 and vimentin were strongly positive, but were negative for S-100 protein. Based on the pathologic findings, the patient was diagnosed as non-neural granular cell tumor (NN-GCT). GCT can be divided into conventional and non-neural GCT by immunoreactivity for S-100 protein. NN-GCT is typically manifested as a well-circumscribed, papulo-nodular dermal mass, and is known to occur in a younger group than does in conventional GCT, but is rare among children. To our knowledge, there have been no case reports of NN-GCT which appeared at birth and presented as grouped nodules. Therefore, we report this interesting case of congenital NN-GCT clinically mimicking NLS.
Subject(s)
Child , Humans , Infant , Biopsy , Coloring Agents , Cytoplasm , Forearm , Granular Cell Tumor , Nevus , Parturition , S100 Proteins , VimentinABSTRACT
BACKGROUND: Usually, we did the fungus culture by collecting nail samples using a surgical blade, but this procedure showed low positive culture rate. An emery board is a tool used to gently grind down and shape the edges of nails. OBJECTIVE: The aim of this study is to compare positive culture rates of nail sampling techniques in diagnosis of onychomycosis using surgical blade and emery board. METHODS: We collected and assessed data of 49 patients in total, with chief complaints of nail problem, and showed positive results in KOH smear. Fungus culture was performed twice in each patient, both by scraping nail with surgical blades and grinding nail piece with emery board. After 4 weeks from culture, we compared positive culture rates of two nail sampling techniques. RESULTS: In 49 patients, 16 patients were male and the other 33 were female, with average age of 51.4 years. When classified by morphological type, there were 45 cases of distal lateral subungual onychomycosis (DLSO) and 4 cases of white superficial onychomycosis (WSO). Culture using emery board produced 18 positive results (36.7%) out of 49 patients, and that using surgical blade produced 9 positive results (18.4%); the difference were statistically significant. In other words, nail sampling using emery board rather than surgical blade resulted in higher positive culture rate. CONCLUSION: Therefore, emery board can be used as a useful device for diagnosis and identification of causative fungi in onychomycosis in clinical practice and a method to enhance positive rates of cultures.
Subject(s)
Female , Humans , Male , Diagnosis , Fungi , Methods , OnychomycosisABSTRACT
BACKGROUND: Psoriasis is associated with increased risk of cardiovascular morbidities, especially in severe cases. Severity of the disease has been known to be associated with higher prevalence of these risk factors. However, in the absence of robust measurements, studies to date relied mostly on treatment spectrum as a proxy for the severity. OBJECTIVE: To evaluate the relationship between psoriasis area and severity index (PASI) and cardiovascular risk factors in Korean patients. METHODS: Presence of diabetes mellitus (DM), hypertension, smoking history was surveyed through questionnaires and serum lipid profile analysis were done after fasting overnight. The severity of psoriasis was assessed using PASI scores: mild, <10; moderate to severe, ≥10. Cardiovascular risk factors such as smoking, hypertension, diabetes and dyslipidemia were compared between the mild group and moderate to severe group. The prevalence of diabetes and hypertension was compared among these two groups of psoriasis patients and the general population based control; age and gender were matched among three groups accordingly prior to analysis. RESULTS: A total of 256 patients with plaque type psoriasis were included. Between mild group and moderate to severe group, significant differences of cardiovascular risk factors including lipid profile were not discovered except in triglyceride level. Comparing to general population, prevalence of diabetes was found significantly higher in psoriasis patients while that of hypertension was similar. CONCLUSION: Our results suggest that among cardiovascular risks, presence of DM and triglyceride level seem to be associated with the presence of psoriasis in Korean psoriasis patients, while other factors may not contribute meaningfully.
Subject(s)
Humans , Diabetes Mellitus , Dyslipidemias , Fasting , Hypertension , Prevalence , Proxy , Psoriasis , Risk Factors , Smoke , Smoking , TriglyceridesABSTRACT
BACKGROUND: Cutaneous angioleiomyoma is a rare and benign smooth muscle tumor derived from the walls of blood vessels. No studies on this condition have been conducted in Korea since a study of 59 cases of angioleiomyoma was reported in 2000. OBJECTIVE: We sought to analyze the clinical and histopathological types of angioleiomyoma in Korea. METHODS: Data were collected from 27 cases of angioleiomyoma in the dermatology department at Hallym University Medical Center. A clinical analysis was conducted through a chart and photographic review. All cases were histologically classified into four types: solid, cavernous, venous, and mixed. RESULTS: The number of males and females was 12 and 15, respectively. The mean age at diagnosis was 41.1 years, and the mean duration of disease was 4.3 years. Lower extremity (63.0%) was the most common site in both, males and females, and the size of tumors did not exceed 2 cm. About half of the patients (51.9%) had pain or tenderness associated with the tumor. The tumors histopathologically were of the solid (16 cases), mixed (6 cases), cavernous (3 cases), and venous (2 cases) types. CONCLUSION: This study will help to improve our understanding of the characteristics of angioleiomyoma in Korea.
Subject(s)
Female , Humans , Male , Academic Medical Centers , Angiomyoma , Blood Vessels , Dermatology , Diagnosis , Korea , Lower Extremity , Smooth Muscle TumorABSTRACT
No abstract available.