ABSTRACT
Objective To study prevalence and risk factors of anemia in adult patients with antineutrophil cytoplasmic antibody (ANCA) associated vasculitis.Methods The clinical data of 72 adult patients with ANCA associated vasculitis were studied retrospectively.According the age,the patients were divided into youth group (age ＜ 65 years,43 cases) and old group (age ≥ 65 years,29 cases).Baseline characteristics and lab measurements were recorded and analyzed.Risk factors of anemia were evaluated using Logistic analysis.Results In 72 adult patients with ANCA associated vasculitis,47 cases (65.3％)developed anemia.The prevalence of anemia in the youth group was 55.8％ (24/43),and that in the old group was 79.3％ (23/29).The prevalence of anemia in the old group was significantly higher than that in the youth group (P ＜ 0.01).When adjusted for confounders,age (increased 10 age,OR =1.23,95％ CI 1.12-1.95,P=0.001),diabetes (OR =1.34,95％ CI 1.14-1.89,P=0.013) and massive proteinuria (OR =1.11,95％ CI 1.05-1.76,P =0.011) were independently associated with increased risk of anemia in all patients.Conclusions The prevalence of anemia in the older patients is higher than that in the younger patients with ANCA associated vasculitis.Age(increased 10 age),diabetes and massive proteinuria are independently risk factor of anemia in adult patients with ANCA associated vasculitis.
ABSTRACT
Objective To analyze the correlation between serum antinucleosome antibody (AnuA) and renal pathological characteristic,disease activity as well as some laboratory tests in patients with lupus nephritis (LN).Methods Serum AnuA levels were detected by enzyme-linked immunosorbant assay in 40 patients with LN (observation group) and 40 healthy people (control group).Renal biopsy was examined in all LN patients.The relationships between serum AnuA level and systemic lupus erythematosus disease activity index (SLEDAI),renal pathohistology,laboratory parameters were analyzed.Results The serum AnuA level in observation group before treatment was significantly higher than that in control group [ ( 110.23 ± 80.48) kU/L vs. ( 10.45 ± 8.20) kU/L,P ＜ 0.05 ].Four cases of renal biopsies were class Ⅱ,8 cases were class m,23 cases were class Ⅳ,and 5 cases were class V.Serum AnuA level had significant difference between each class by Kruskal-Wallis rank sum test (P ＜ 0.05),and serum AnuA level of class Ⅳ was the highest (P ＜ 0.05).Serum AnuA level had positive correlation with SLEDAI,urine protein quantitation and anti-double strands DNA antibody (r =0.462,0.521,0.394,P ＜0.05),negative correlation with complement C3 and C4 levels (r =-0.403,-0.489,P ＜ 0.05 ).Serum AnuA level after treatment [ (32.45 ± 18.31) kU/L] was significantly decreased than that before treatment [(110.23 ± 80.48) kU/L](P＜0.05).Conclusions Serum AnuA level is not only a good index of LN activity,but also reflect renal involvement.That serial measurement of serum AnuA level may provide better clinical strategies for the therapy.