ABSTRACT
OBJECTIVE@#To systematically evaluate the effect of statins on prognosis for patients with cancers. @*METHODS@#Literature on PubMed, EMbase and Cochrane library was screened from the establishment of databases to March, 2015 to find relevant studies. Random-effects models were used to calculate the pooled hazard ratios (HR) and 95% confidence interval (CI) for the association between statin use and all-cause mortality and cancer-specific mortality. @*RESULTS@#A total of 25 studies covered 523 193 patients were identified and included in this Meta-analysis. The pooled effect showed that statin application was associated with a reduction in all-cause mortality in cancer patients (HR, 0.82; 95% CI: 0.76 to 0.89). A significantly decreased mortality in prostate cancer was revealed in subgroup by cancer sites (HR, 0.66; 95% CI: 0.52 to 0.83). In addition, sensitivity analysis demonstrated a weakened association between statin application and all-cause mortality after excluding the studies with shorter follow-up duration (HR, 0.91; 95% CI: 0.75 to 1.10). @*CONCLUSION@#A beneficial effect of statin on all-cause mortality and cancer-specific mortality is presented in patients with cancer. However, further studies are needed to confirm the long term effect.
Subject(s)
Humans , Male , Hydroxymethylglutaryl-CoA Reductase Inhibitors , Therapeutic Uses , Neoplasms , Drug Therapy , Mortality , Prognosis , Prostatic Neoplasms , Drug Therapy , MortalityABSTRACT
OBJECTIVE@#To determine whether serum adipocytokines and leptin level are associated with bone mineral density (BMD) in postmenopausal women.@*METHODS@#Serum adiponectin and leptin level were measured by ELISA in 336 postmenopausal women. BMD was measured by dual energy X-ray absorptiometry (DXA) at the whole body, lumbar spine, hip, and forearm. Body compositions including lean tissue mass and body fat mass were measured by DXA, and their relationship was analyzed.@*RESULTS@#Serum adiponectin levels were negatively related to BMD at the whole body, the lumbar spine, the hip, and the forearm (r = -0.181, r = -0.208, r = -0.228, r = -0.203, and P < 0.05, respectively). After adjustment for age and fat mass, the correlation with BMD still remained (r = -0.131, r = -0.140, r = -0.159, r = -0.172, and P<0.05, respectively). Serum leptin levels were positively related to BMD was at the hip and the forearm (r = 0.162, r = 0.210, and P < 0.05, respectively). After adjustment for age and fat mass, the correlation with BMD at the forearm remained (r = 0.157, P<0.05), but the correlation with BMD at the hip disappeared. In the multiple linear stepwise regression analysis, year since menopause, lean mass, adiponectin, and estradiol were independent predictors of BMD at the body, the hip and the forearm; year since menopause, lean mass, body mass index, adiponectin, and extradiol were independent predictors of BMD at the lumbar spine.@*CONCLUSION@#Adiponectin is the independent predictor of BMD.
Subject(s)
Aged , Aged, 80 and over , Female , Humans , Middle Aged , Absorptiometry, Photon , Adiponectin , Blood , Bone Density , Physiology , Enzyme-Linked Immunosorbent Assay , Leptin , Blood , Postmenopause , Blood , MetabolismABSTRACT
OBJECTIVE@#To investigate the relationship between serum follicle-stimulating hormone (FSH) level with bone mineral density (BMD), and the risk rate of osteoporosis in Chinese women.@*METHODS@#Serum FSH concentrations of 699 healthy Chinese women aged 20-82 years were measured by radioimmunoassay (RIA). BMD was measured by dual-energy-X-ray absorptiometry (DXA) at the postero-anterior spine, lateral spine, total hip, and ultra-distal forearm.@*RESULTS@#The level of serum FSH started to increase from 40 years old, and then decreased after 60. Serum FSH level was negatively related to BMD at various sites. At the postero-anterior spine, lateral spine, total hip, and ultra-distal forearm, 4 quartiles of average prevalence of osteoporosis (OP) divided by FSH were 0.57%, 0.43%, 27.1%, and 30.9%, respectively. Compared with the 1st and the 2nd quartile, OP case rate and ill risk in the women of the 3rd and the 4th quartile increased notably, especially in the spine.@*CONCLUSION@#The level of serum FSH may be related to bone loss and the occurrence of osteoporosis in Chinese women.