ABSTRACT
OBJECTIVE: To clarify the importance of clinical pharmacists participating in the management of polypharmacy in comprehensive geriatric assessment. METHODS: The role of clinical pharmacists in the comprehensive geriatric assessment team was revealed through assessment of polypharmacy in one case of elderly outpatient's prescription. RESULTS: Clinical pharmacists successfully involved in the development of polypharmacy programs in the comprehensive geriatric assessment team. CONCLUSION: Comprehensive geriatric assessment can optimize the clinical treatment of elderly patients. Clinical pharmacist is an important member of the management of polypharmacy in the comprehensive geriatric assessment team. Hope that more clinical pharmacists to participate in this work, to provide quality pharmaceutical care for elderly patients.
ABSTRACT
<p><b>OBJECTIVE</b>To establish an HPLC method for determination of chlorogenic acid and baicalin in Yinhuang film-coated tablets.</p><p><b>METHOD</b>HPLC isocratic elution was adopted, with the C18 column (4.6 mm x 250 mm, 5 microm) as the chromatographic column, methanol-water-phosphoric acid (45: 55: 0.2) as the mobile phase. The flow rate was set at 1.0 mL x min(-1), and column temperature was set at 30 degrees C. The detection wavelength was 328 nm, and the sample size was 20 microL.</p><p><b>RESULT</b>At concentrations ranging between 2.200-44.00, 24.20-242.0 mg x L(-1), peak area of chlorogenic acid and baicalin showed good linear relationship, the average recoveries were 99.63% (RSD 1.8%, n = 9) and 99.72% (RSD 1.9%, n = 9), respectively.</p><p><b>CONCLUSION</b>The method is simple that it can accurately measure the content of chlorogenic acid and baicalin in Yinhuang film-coated tablets.</p>
Subject(s)
Chlorogenic Acid , Chemistry , Chromatography, High Pressure Liquid , Methods , Drugs, Chinese Herbal , Chemistry , Flavonoids , Chemistry , Linear Models , TabletsABSTRACT
<p><b>OBJECTIVE</b>To explore the safety and efficiency of endovascular repair (EVAR) of abdominal aortic aneurysms (AAAs) which have the complex aortic anatomy.</p><p><b>METHODS</b>The clinical date of 48 AAA patients with complex aortic anatomy treated by EVAR from January 2003 to March 2011 was retrospectively analyzed. There were 37 male and 11 female patients, aged from 50 to 81 years with a mean of 71.4 years. Fourteen patients had short aortic neck (< 15 mm), 13 patients had severe infrarenal angulation (> 60°), 15 patients had severely tortuous iliac, 6 patients had small iliac (< 8 mm). The stent-grafts were deployed by both femoral arteries to treat the AAA.</p><p><b>RESULT</b>The primary technical success rate was 100%. The perioperative survival rate was 100%. Intraoperative angiograms revealed two type I endoleaks, in which one disappeared in two weeks, another existed. Follow-up was available in 40 patients with a median of 63 months (4 to 122 months). During the follow-up period, 2 patients died with no relationship to the procedures. The rest patients survived well. The accumulative survival rate was 95.8%. There were no new endoleak, stent-graft migration, aneurysm expansion, or secondary intervention during the follow-up time.</p><p><b>CONCLUSIONS</b>EVAR is safety and efficiency to treat the patient of infrarenal abdominal aortic aneurysm with the complex aortic anatomy. By the accumulation of experience, EVAR will play a more important role for these patients.</p>