Synthesis and antioxiactivity of squamosamide cyclic analogs / 中国医学科学院学报

<p><b>OBJECTIVE</b>To design and synthesize a series of squamosamide cyclic analogues and to test their antioxidation activity.</p><p><b>METHODS</b>Eleven 3-substituted indole-2-one derivatives were designed and synthesized through 9 steps with p-hydroxyphenylacetic acid as the starting material and their structures were confirmed by nuclear magnetic resonance and mass spectrometry.</p><p><b>RESULTS</b>Eleven compounds showed antioxidation activity and the activities of compounds 9 and 13 matches the positive control FLZ-52.</p><p><b>CONCLUSION</b>Cyclic reconstruction with FLZ-52 as the lead compound have some antioxidation activity.</p>