ABSTRACT
Ovarian cancer is a common gynecological malignancy and the most common cause of cancer death. Ovarian cancer is usually treated with surgery combined with chemotherapy as the preferred treatment. In recent years, with the continuous development of medical technology and the in-depth research on ovarian cancer at home and abroad, the molecular targeted therapy of ovarian cancer has received extensive attention. Among them, the poly ADP-ribose polymerase (PARP) inhibitors have made great breakthroughs and advances in the precise and standardized treatment of ovarian cancer. This paper discusses the study of PARP inhibitors in sensitivity biomarkers of ovarian cancer, and reviews the standardized treatment of PARP inhibitors in maintenance therapy of ovarian cancer.
ABSTRACT
Cervical cancer is the second most common female reproductive system tumor in developing countries and ranks second among female cancer deaths worldwide. In recent years, with the continuous optimization and popularization of cervical cancer screening and preventive measures, the overall incidence rate of cervical cancer has decreased. But the incidence rate of cervical cancer in China is younger and differentiated. It continues to threaten the fertility, reproduction, mental health and life safety of women in China. In view of the current difficulties, precision medicine initiative (PMI) has opened a new chapter in the individualized prevention and treatment of cancer. Chinese medical workers need to learn from the beneficial results of international research organizations on early screening and prevention of cervical cancer, and explore the appropriate early screening and prevention strategies for cervical cancer in China.
ABSTRACT
Organ transplantation is one of the effective methods for the treatment of end-stage diseases, but the lack of donors has hindered the development of organ transplantation. Extracorporeal membrane oxygenation (ECMO) can improve the hypoxia and hypoperfusion of organs, shorten the warm ischemia time, and maintain the function of donor organs effectively, in case of emergency or donor hemodynamic instability. It helps to make effective use of donor organs and benefit patients who are in urgent need of organ transplants. This article summarized the progress on application of ECMO in donor maintenance and provided suggestions for its application in organ transplantation.
ABSTRACT
The concept of enhanced recovery after surgery has been widely used in various disci-plines. Because of the need of anaesthesia and metabolism after surgery and the particularity of gynecologi-cal pelvic surgery, most surgical operations require indwelling catheter. However, indwelling catheter has many complications, such as urinary tract infection, difficult intubation, leakage, bladder function damage and difficult extubation. This article mainly discussed the progress of rehabilitation surgery and the applica-tion of early removal of ureter, and discussed the complications of indwelling catheter, in order to shorten the time of indwelling catheter after surgery, so as to reduce the symptoms of urinary tract irritation, the rate of urinary tract infection, and the nervous and anxious mood of patients, as well as accelerate the recovery of patients after surgery.
ABSTRACT
Chloride Channel-3 (ClC-3) is a member of the Cl2 channel superfamily,which is encoded by CLCN3 gene.It involves regulating electrical activity,cell volume,proliferation,migration,invasion,apoptosis and intracellular pH,which have become a hot spot of current research.In recent years,the research of ClC-3 in gynecological diseases is increasing day by day.This article will review the research progress of ClC-3 and benign and malignant gynecological diseases,especially the relationship between ClC-3 and the occurrence and development of endometriosis.
ABSTRACT
Pelvic abscess is one of the most common gynecologic acute abdomen.It is often developed by pelvic inflammatory disease,and the incidence of the pelvic abscess is rising year by year and younger.It often leads to a variety of diseases,such as infertility,which threaten female reproductive health.Its clinical symptoms vary and progress rapidly,which can easily lead to misdiagnosis or untimely rupture of abscess,and seriously endanger life.For pelvic abscess,correct diagnosis and timely treatment are the fundamental starting point.This article reviews the progress in the diagnosis and treatment of pelvic abscess.
ABSTRACT
High mobility group protein B1 (HMGB1) is a DNA binding protein that can induce cytokines to be secreted and activate inflammatory cells to participate in inflammatory reactions. Recent studies on its role in the inflammatory response to endometriosis have gradually increased. Endometriosis is a benign inflammatory disease with increasing incidence year by year, mostly in women of childbearing age. This disease mainly causes the clinical manifestations of dysmenorrhea and chronic pelvic pain. Endometriosis usually plays a synergistic role in inflammatory immune, lesion tissue invasion, adhesion and other factors, resulting the changes in the pelvic microenvironment. The mechanism of endometriosis is not completely clear, but the role of inflammatory reaction and stimulation can not be ignored. HMGB1 can increase the release of inflammatory factors and cause the body to produce pain, and the expression of HMGB1 in the endometriosis patients is significantly increased. The inflammatory response and pain can be alleviated by reducing the concentration of HMGB1 in the body of endometriosis patients. Pain and other symptoms suggest that HMGB1 may become an important target for the treatment of endometriosis.
ABSTRACT
Uterine artery embolization (UAE) is the purpose of treatment-related diseases by embolizing the vascular network of uterine lesions. Because of the small damage, the recovery time of patients is short, and it is recognized by the majority of patients. However, it is still important to pay attention to the poor effect and complications of 10% of the patients. Three-dimensional reconstruction of the lesion before surgery, could calculate the optimal angle of inclination of the tube to guide uterine artery embolization, reduce the X-ray. Radiation dose, exposure time and rational distribution of embolic agents to achieve personalized guidance for UAE. Now, we elaborate the research progress of three-dimensional reconstruction in the application of uterine artery embolization in gynecological diseases.
ABSTRACT
Objective To observe the effects of family cognitive training on patients with vascular cognitive impairment but without dementia.Methods Sixty patients with non-dementia type vascular cognitive impairment were divided at random into a group which received family cognitive training (30 cases) and a control group (30 cases).The 2 groups all took routine drugs and exercise.The family cognitive training group received cognitive training additionally.Before treatment and after 1 and 6 months of treatment,all of the patients of both groups were assessed using the mini-mental state examination (MMSE),the Montreal cognitive assessment (MoCA) and the modified Barthel index (MBI).Results After 1 month of treatment there was no significant difference between the 2 groups in any of the assessments.After6 months the scores on each item of the MMSE,MoCA and MBI had improved significantly more in the family cognitive training group than in the control group.Conclusion Family cognitive training is effective in treating non-dementia type vascular cognitive impairment.It can delay disease progression and improve cognitive function and ability in the activities of daily living.
ABSTRACT
Objective To explore the relationship between the timing of functional training and its therapeutic effects on patients with cerebral infarction. Methods One hundred and fifty-six patients with cerebral infarction of internal carotid artery system were randomly and equally divided into three groups (groups A, B and C), and the functional training was initiated within 7d, 7～30d or over 30d after cerebral infarction in groups A, B, C, respectively. The effects were evaluated at 91d after the functional training. Results Compared with those of group C, the therapeutic effects in groups A and B were significantly better (P
ABSTRACT
Objective:To investigate the value of serum matrix metalloproteinases- 9(MMP-9) level in the diagnosis of recurrence of endometriasis(EMs) after operation.Methods:Sixty-nine patients who had a previous operations for endometriosis were recruited in the study from February 2002 to March 2005. All the patient were examined by laparoscopy 6-12 months later after surgery. The serum were collected from the 69 patients and 25 health women for MMP-9 level measurement. ELISA was used to measure the level of serum MMP-9.Results:Twenty-two recurrent patients were diagnosed by Laparoscopy. The level of serum MMP-9 were 252.21?17.90 ng/ml in patients with recurrent endometriosis, 31.26?1.84 ng/ml in patients without recurrent endometriosis, 12.93?0.57 ng/ml in women without endometriosis. There was a clinical significance between the recurrent endometriosis group and non-recurrent endometriosis group and health women. The sensitivity for detection of recurrent endometriosis was 90.9% and the specificity was 85.1% using serum MMP-9 profile.Conclusion:Serum MMP-9 measurement is a sensitive, specific and non-invasive methods for the diagnosis of recurrent endometriosis.