ABSTRACT
To compare the economic efficacies of the oral antidiabetic drugs in National Essential Medicine for treating type 2 diabetes mellitus.200 diabetic patients with body mass indices between 19-27 kg/m2 were assigned into 5 groups:group A received glibenclamide,group B glipizide,group C metformin,group D glibenclamide +metformin,and group E glipizide + metformin.Pharmacoeconomic evaluation was performed by cost-effectiveness analysis( CEA ).Fasting glucose level in patients treated with these 5 drugs all decreased significantly,as well as HbA1c.Glibenclamide was more in line with the principles of pharmacoeconomics,but should be used carefully for its serious and prolonged hypoglycemia,especially in elderly patients.According to the method of cost-effectiveness analysis,it was more economical to use metformin to control fasting glucose level while it is more reasonable to use glipizide to control the postprandial glucose whereas controlling of postprandial blood glucose is considered as a priority.Glipizide+mefformin combination may be recommended to the patients whose blood glucose level is poorly controlled by a single drug alone.
ABSTRACT
OBJECTIVE: To establish HPLC method for the determination of acipimox in human serum. METHODS: The determination was performed on C18 column under room temperature, the mobile phase consisted of methanol -water(15:85) with a flow rate of 0.8ml/ min and detection wavelength of 260nm, the quantitation was conducted by external reference method,the serum was subjected to protein sediment by methanol,the supernate fluid obtained thereafter was undergone sample injection. RESULTS: The linear range of acipimox was 1.0-16.0?g/ml (r = 0.9 987),the minimum detection concentration was 0.5?g/ ml; the average recovery of method was 96.05% . CONCLUSION: This method is simple, fast, sensitive and accurate, and which can be applied for blood concentration monitoring and pharmacokinetic study of acipimox.
ABSTRACT
OBJECTIVE:To study human body bioavailability of trosipide capsules and tablets.METHODS:18healthy men volunteers were administered randomly with cross single dose of capsules or tablets of trosipide.The blood concentrations of which were determined by HPLC and the pharmacokinetic parameters and the relative bioequivalency were calculated with3p97program.RESULTS:The human body concentration-time curves of capsules and tablets of trosipide were in line with two compartment model.The C max of capsules and tablets of trosipide were(1.01?0.26)?(0.99?0.35)?g/ml respectively;the T max were(3.39?1.04)?(3.33?1.19)h respectively;the AUC 0～48 were(10.16?2.40)?(10.46?2.85)(?g?h)/ml respective_ ly and the t 1/2ke were(5.60?0.22)?(6.50?2.35)h respectively.The relative bioavailability of troxipide capsules was(96.85?24.1)%.CONCLUSION:Troxipide capsules and tablets were bioequivalent.