Clone of M2 autoantigens from human sources and evaluation of measurement of M2 autoantibodies in diagnosis of primary biliary cirrhosis / 中华肝脏病杂志

<p><b>OBJECTIVE</b>To evaluate the value of measurement of M2 autoantibodies in diagnosis of primary biliary cirrhosis (PBS).</p><p><b>METHODS</b>M2 autoantibodies were detected by ELISA combined with western-blot.</p><p><b>RESULTS</b>Thirty-two cases presented positive M2 autoantibodies, including 20 cases of PBC, 9 liver diseases of unknown etiology, 1 autoimmune hepatitis and 1 drug-induced liver injury.</p><p><b>CONCLUSIONS</b>M2 autoantibodies show good sensitivity and specificity to diagnosis of PBC. It should be used as a powerful and specific maker for the diagnosis of PBC</p>