ABSTRACT
OBJECTIVE@#To observe the effect on the inhibition of coronary atherosclerosis hardening of the paraoxonase gene (PON-1) which transfected to the rabbit epicardial adipose tissue.@*METHODS@#Rabbit coronary atherosclerosis model was established by high-fat feeding, liposome-encapsulated recombinant plasmid pEGFP-PON-1 50 μ L was injected to the rabbit pericardial cavity, and was harvested 4 weeks after transfection.@*RESULTS@#The epicardial fat transfected PON-1 gene had effect on the high lipid level. It significantly increased expression of PON-1 in peripheral arterial vascular tissue (P <0.05); and significantly reduced total cholesterol and low-density lipoprotein cholesterol levels (P<0.05), and the thickness ratio of coronary artery intima/media (P <0.05).@*CONCLUSIONS@#The injection of the PON-1 gene in the pericardial cavity can effectively suppress the formation of coronary atherosclerosis.
Subject(s)
Animals , Male , Rabbits , Analysis of Variance , Aryldialkylphosphatase , Genetics , Pharmacology , Cholesterol , Metabolism , Coronary Artery Disease , Genetics , Genetic Therapy , Methods , Injections , Random Allocation , Transfection , Triglycerides , MetabolismABSTRACT
<p><b>OBJECTIVE</b>This prospective and randomize-controlled trial was designed to investigate the effects of antiarrhythmic drug use (AADs) on atrial fibrillation (AF) recurrence in atrial fibrillation patients post circumferential pulmonary vein ablation (CAPV).</p><p><b>METHODS</b>Seventy-four consecutive AF patients underwent CAPV (41 paroxysmal and 33 drug refractory AF) were randomly assigned to receive placebo (Group A) or AADs (Group B) for 3 months. Monthly standard electrocardiograms (ECG) and Holter monitoring were performed to assess AF recurrences during 17 - 28 months follow-up.</p><p><b>RESULTS</b>CAPV was successful in all patients. The recurrence rate of AF in Group B was significantly lower than that in Group A at 3 months post CAPV (13.5% vs. 37.8%, P < 0.01) and similar thereafter (29.7% vs. 24.3% at 12 months and 8.1% vs. 8.1% at more than 12 months, all P > 0.05). There was also no significant difference in terms of total recurrence rate between the two groups (37.8% vs. 32.4%, P > 0.05).</p><p><b>CONCLUSION</b>Post CAPV antiarrhythmic drug therapy could only decrease the early AF recurrence rate but was not effective for decreasing AF recurrence rate on later stage.</p>
Subject(s)
Adult , Aged , Female , Humans , Male , Middle Aged , Anti-Arrhythmia Agents , Therapeutic Uses , Atrial Fibrillation , Drug Therapy , Therapeutics , Catheter Ablation , Methods , Postoperative Period , Prognosis , Prospective Studies , Pulmonary Veins , RecurrenceABSTRACT
Objective To investigate the effects of rehabilitation and exercise training on endothelial func- tion and collateral circulation in patients with coronary heart disease(CHD)who underwent PCI.Methods Sixty- three cases were divided into three groups:group A undertook rehabilitation protocol with three stages,group B with additional extracorporeal counterpulsation in addition to the intervention of group A,group C acted as control.The Bruce submaximal treadmill,coronary angiography and Doppler were conducted for evaluation of the functional per- formance,lateral branching and endothelium function.Results(1)The value of RPP and RPE of groups A and B were significantly higher than those of the control group as quantified by exercise test alter the third stage of rehabilita- tion(P