ABSTRACT
The growth of solid tumors is dependent on new blood vessels generated from existed ones,that is tumor angiogenesis.Much material consumption is required in the invasion and metastasis of malignant tumors,to meet the own needs of oxygen and nutrients and remove the metabolic wastes from them,tumor cells will generate new vasculature through different ways.Vasculogenic mimicry is a kind of angiogenesis dominated by tumor cells,it is one style of vascular pattern that is different from traditional endothelial cells pattern.Vasculogenic mimicry plays an important role in the invasion and metastasis of tumors.This article will review the relationship between vasculogenic mimicry and tumor invasion and metastasis,tumor angiogenesis,and related signaling pathways.
ABSTRACT
Human 8-oxoguanine DNA glycosylase [hOGG1] plays a pivotal role in the initiating and progression of pancreatic cancer.Many studies implicated the association of hOGG1 polymorphism and pancreatic cancer susceptibility. However, the results remained inconclusive. The purpose of this meta-analysis was to investigate the relationship between hOGG1 polymorphism and pancreatic cancer susceptibility. Retrieved studies from Pubmed, Embase, Web of Science, Cochrane Library, and CBM databases about hOGG1 polymorphism and pancreatic cancer susceptibility were included in the final analysis with definite selection. Odds ratio [OR], 95% confidence interval [CI] and publication bias were calculated. Five related studies on hOGG1 polymorphisms [S326C, T2657C and R229Q] and pancreatic cancer susceptibility were included with 1,897 cases and 4,320 controls. The pooled results showed that hOGG1 polymorphisms S326C, T2657C, and R229Q were not associated with pancreatic cancer risk without publication bias. The current meta-analysis indicated that hOGG1 polymorphisms [S326C, T2657C and R229Q] are not associated with pancreatic cancer risk, but it needs further larger studies with ethnicity and various etiologies
ABSTRACT
Histone deacetylase7 (HDAC7) belongs to Ⅱ a histone deacetylases.HDAC7 can alter chromosome structure and regulate gene transcription,and plays an important role in tumorigenesis and tumor angiogenesis.Increasing evidences show that HDAC7 can maintain the vascular integrity and continuity,and regulate the expression of angiogenic genes.HDAC7 also can regulate the migration and proliferation of vascular endothelial cells,and regulate angiogenic effect mediated by VEGF and other proangiogenenic factors contributing to tumor angiogenesis.Therefore,studies of the mechanisms in which HDAC7 contributes to tumor angiogenesis and the development of HDAC7 inhibitors could provide a new direction to tumor diagnosis and therapy.