ABSTRACT
Objective To compare the clinical efficacies between open resection and laparoscopic resection for gastrointestinal stromal tumors (GISTs) of stomach, and to discuss the indications of laparoscopic resection for GISTs. Methods A retrospective analysis was conducted in 174 patients with GISTs undergoing either open (open resection group [ORG], n = 76) or laparoscopic resection (laparoscopic resection group [LRG], n=98) from July 2008 to April 2014 at Changhai Hospital. The patients, according to tumor size (max diameter), were divided into two subgroups: <5 cm (113 cases: 35 cases for ORG and 78 cases for LRG), ≥5 cm and ≤10 cm (61 cases: 41 cases for ORG and 20 cases for LRG). The data for analysis included gender, age, tumor size, risk grading, mitotic rate, surgical type, operative time, intraoperation blood loss, postoperative hospital stay, postoperative feeding time, and 5-year tumor-free survival time, etc. Results The gender, age, tumor size, risk grading, mitotic rate and surgical type of patients had no significant differences between the laparoscopic and open resection groups for the two tumor size groups. When the tumor size <5 cm, the operation time was similar for the two surgical approaches, but the blood loss, postoperative hospital stay and postoperative feeding time were significantly reduced in LRG compared with ORG (P<0. 01). When the tumor size ≥5 cm and ≤10 cm, the operation time and postoperative hospital stay were similar between ORG and LRG, but the blood loss and postoperative feeding time of LRG were significantly less than those of ORG (P<0. 05). The 5-year tumor-free survival time was not significantly different between LRG and ORG for the two tumor size groups. Conclusion When the tumor size is <5 cm, laparoscopic resection is more safe and reliable than open resection for the gastrointestinal stromal tumor of stomach; when the tumor size is ≥5 cm and ≤10 cm, laparoscopic resection is safe and feasible after appropriate preoperative evaluation and patient selection.
ABSTRACT
<p><b>OBJECTIVE</b>To investigate composition principles of Gegen Qin Lian decoction through anti-pyretic experiment.</p><p><b>METHOD</b>Pharmacological effects of different compounds of Gegen Qin Lian decoction according to six hours temperature response index (TRI6) and average top temperature response height (deltaT) after the decoction was given to feverish animal model by inactived bacteria suspension.</p><p><b>RESULT</b>As for reducing six hour temperature response index, Scutellaria baicalensis root was the main effective drug. Pueraria lobata root could enforce the effect while Coptis chinensis rhizome and Glycyrrhiza uralensis root counteracted it. As for reducing average top temperature response height, the Effects of four herbal drugs were the same as for TRI6.</p><p><b>CONCLUSION</b>Of the compounds of Gegen Qin Lian decoction, as to the pharmcological anti-pyretic effects, the best one is the compound of Scutellaria baicalensis and Pueraria lobata roots.</p>