ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the academic level and influence of "Chinese Journal of Applied Physiology" through statistical analysis for the fund sponsored articles published in the recent ten years.</p><p><b>METHODS</b>The articles of "Chinese Journal of Applied Physiology" from 1999 to 2008 were investigated. The number and the percentage of the fund sponsored articles, the fund organization and the author region were quantitatively analyzed by using the literature metrology method.</p><p><b>RESULTS</b>The number of the fund sponsored articles increased unceasingly. The ratio of the fund from local government significantly enhanced in the latter five years. Most of the articles were from institutes located at Beijing, Zhejiang and Tianjin.</p><p><b>CONCLUSION</b>"Chinese Journal of Applied Physiology" has a fine academic level and social influence.</p>
Subject(s)
Bibliometrics , China , Periodicals as Topic , PhysiologyABSTRACT
<p><b>AIM</b>To observe the expressional alterations of colony stimulating factor-1 receptor (CSF-1R) after ischemic injury of cerebral cortex, and study the function of colony stimulating factor-1 (CSF-1)/CSF-1R signal during the process of ischemic injury and repair of central nervous system (CNS).</p><p><b>METHODS</b>We examined the distribution and expression of CSF-1R in normal brain tissues and ischemic brain tissues by immunohistology and Western blot analysis.</p><p><b>RESULTS</b>The expression of CSF-1R in neurons could be up-regulated by ischemic injury in CNS.</p><p><b>CONCLUSION</b>CSF-1/CSF-1R might take part in the process of ischemic injury and repair.</p>
Subject(s)
Animals , Female , Male , Mice , Brain Ischemia , Pathology , Cerebral Cortex , Macrophage Colony-Stimulating Factor , Physiology , Mice, Inbred BALB C , Neurons , Metabolism , Random Allocation , Receptor, Macrophage Colony-Stimulating Factor , Genetics , Metabolism , Physiology , Reperfusion Injury , MetabolismABSTRACT
<p><b>AIM</b>To study the protective effect of Quinacrine(QA) on rat striatum neurons from the injury caused by heat environment treatment, to probe the relationship between cell membrane injury and cellular injury protection, and to seek the possibility of QA as a preventive agent to heat injury.</p><p><b>METHODS</b>Primary cultured striatum neurons from newborn rats were pretreated with QA at different concentration for 1 h, and then heat-treated at 43 degrees C for another 1 h. Cell necrosis was detected by Trypan blue staining, and apoptosis was evaluated through Activated Caspase-3 dye and TdT dye.</p><p><b>RESULTS</b>Heat treatment effected the survival of striatum neurons and resulted in great number of cell death, which was mainly mediated by cell necrosis process. It was shown that treatment of QA itself had little effect on the survival of striatum neurons, while QA pretreatment decreased cellular necrosis caused by following heat treatment.</p><p><b>CONCLUSION</b>QA protects striatum neurons from heat environment injury at about 20 pmol/L, and the protection may mediated by reduction of necrosis.</p>