ABSTRACT
This study aimed to investigate thiol-disulfide balance in patients with renal colic who were frequently referred to emergency services and also to discuss its potential clinical use. Blood samples were obtained from 32 patients diagnosed with renal colic before treatment in the emergency department. Then, the serum thiol-disulfide levels were measured using a novel method. The patients also underwent a complete blood count test and renal ultrasonography. The thiol-disulfide values were compared statistically between the patient [those with renal colic] and control groups [healthy volunteers]. The mean native thiol level was significantly less in the patient group than in the control group. In addition, the disulfide/ native thiol and disulfide/total thiol ratios were significantly higher in the patient group than in the control group [P < 0.05]. This study found a significant difference in the thiol-disulfide balance of patients with renal colic compared with healthy volunteers. The mean native thiol and total thiol levels decreased in the patient group. It is believed that these markers may be indicative of inflammation in patients with renal colic.
ABSTRACT
This study aimed to assess the diagnostic value of thiol-disulfide homeostasis in patients with acute appendicitis [AA]. A total of 43 patients diagnosed with acute appendicitis in the emergency department and 59 healthy individuals were evaluated. Age, gender, white blood cell count, and thiol-disulfide homeostasis parameters [native thiol, total thiol, disulfide, disulfide/native thiol, native thiol/total thiol, and disulfide/total thiol ratios] were compared between groups. Thiol-disulfide homeostasis was determined using a newly developed method by Erel and Ne?elio?lu. White blood cell counts were statistically significantly higher in the AA group, but no significant difference [P = 0.742] was found between native thiol, total thiol, and disulfide levels of the patient and control groups. Also, no statistically significant difference was observed in disulfide/native thiol, disulfide/total thiol, and native thiol/total thiol ratios [P = 0.117] between groups. This was thought to be a result of early diagnosis of AA in patients at the emergency department. Hence, the inflammatory response did not increase significantly at the time of diagnosis