ABSTRACT
Background: Vildagliptin is a dipeptidyl peptidase IV inhibitor (DPP4i). Its efficacy and safety of DPP4i in Chilean real life type 2 diabetic (T2D) patients is not well known. Aim: To assess the safety profile and effectiveness of 12 weeks of treatment with Vildagliptin for glycemic control in T2D Chilean patients with a poor glycemic control. Patients and Methods: Retrospective assessment of the effects of Vildagliptin treatment during 12 weeks in 103 T2D patients aged 29 to 92 years (47% males). The main outcomes were changes in glycosylated hemoglobin and the occurrence of adverse effects. Results: After 12 weeks of Vildagliptin use, glycosylated hemoglobin decreased from 8.3 ± 1.4 to 7.2 ± 1.1% (p < 0.01). Fasting plasma glucose and the number of hypoglycemic events also decreased significantly. No significant weight change was observed. The treatment had good compliance, tolerance and patient satisfaction. Conclusions: Vildagliptin treatment reduced glycosylated hemoglobin by 1.1% and was well tolerated in this group of diabetic patients.
Subject(s)
Saccharomyces cerevisiae Proteins/metabolism , Saccharomyces cerevisiae/metabolism , Telomerase/metabolism , Mutation , Protein Binding , Protein Structure, Tertiary , Recombinant Proteins/genetics , Recombinant Proteins/metabolism , Saccharomyces cerevisiae Proteins/genetics , Saccharomyces cerevisiae/genetics , Telomerase/geneticsABSTRACT
El Comité de Normas de la Society of Critical Care Medicine, ha recientemente efectuado una revisión que se detalla a continuación y que servirá como una guía para los hospitales, en la formulación de las normas que servirán a modo de referencia, para diseñar nuevas unidades de cuidados intensivos o para modificar las actualmente existentes. Cada unidad debería elaborar sus propias normas de ingreso y de egreso de pacientes, utilizando el modelo que aquí se presenta solamente como una pauta. Por lo demás cada hospital debiera desarrollar su propia estrategia para poder acomodar pacientes cuando la UCI se encuentra completa, las que deben periódicamente ser revisadas