ABSTRACT
The category Ⅱ fetal heart rate(FHR)tracings,which have various forms,are the common patterns of electronic fetal monitoring(EFM)during labor.The correct identification and assessment of categoryⅡ FHR tracings,as well as the targeted intervention according to specific clinical conditions,can reduce the occurrence of adverse pregnancy outcomes.This article introduces the intrapartum management process of categoryⅡFHR tracings according to the three-tier system for the categorization of intrapartum EFM,and expounds the causes and intervention measures of different types of categoryⅡFHR tracings,so as to guide clinical practice.
ABSTRACT
<p><b>OBJECTIVE</b>To assess the efficacy of dapoxetine on demand for premature ejaculation and provide evidence for clinical decision-making.</p><p><b>METHODS</b>We searched PubMed, Embase, BIOSIS Previews, Cochrane Library, CNKI Database and Wanfang Database for literature on dapoxetine on demand for premature ejaculation. We performed meta-analysis on the identified publications and evaluated its therapeutic efficacy based on the intravaginal ejaculatory latency time (IELT), patient-reported global impression of change (PGI), and composite PRO criteria for clinical benefit (CCCB).</p><p><b>RESULTS</b>Four relevant studies were included involving 6 081 cases of premature ejaculation. Compared with the placebo controls, the patients treated with dapoxetine on demand showed significant improvement in IELT (WMD = 1.39, 95% CI [1.23, 1.55], P < 0.000 01), PGI (OR = 2.59, 95% CI [2.21, 3.04], P < 0. 000 01), and CCCB (OR = 2.59, 95% CI [1.98, 3.39], P < 0.000 01). There were significant differences between the 60 mg and 30 mg dapoxetine groups in IELT (WMD = 0.46, 95% CI [0.19, 0.74], P = 0.001 0) and PGI (OR = 1.32, 95% CI [1.06, 1.64], P = 0.01), but not in CCCB (OR = 1.39, 95% CI [0.90, 2.15], P = 0.13).</p><p><b>CONCLUSION</b>Dapoxetine on demand can prolong IELT and improve PGI and CCCB, either at the dose of 60 mg or 30 mg, and has an even better efficacy in prolonging IELT and improving PGI at 60 mg.</p>
Subject(s)
Humans , Male , Benzylamines , Therapeutic Uses , Ejaculation , Naphthalenes , Therapeutic Uses , Premature Ejaculation , Drug Therapy , Treatment OutcomeABSTRACT
This study was aimed to evaluate the impact of regular donating platelets on serum ferritin (SF) of donors. A total of 93 male blood donors including 24 initial plateletpheresis donors and 69 regular plateletpheresis donors were selected randomly. Their SF level was measured by ELISA. The results showed that the SF level of initial plateletpheresis donors and regular plateletpheresis donors were 91.08 ± 23.38 µg/L and 57.16 ± 35.48 µg/L respectively, and all were in normal levels, but there was significant difference between the 2 groups (p < 0.05). The SF level decreased when the donation frequency increased, there were no significant differences between the groups with different donation frequency. Correlation with lifetime donations of platelets was not found. It is concluded that regular plateletpheresis donors may have lower SF level.