ABSTRACT
Objective To investigate the curative effect of sodium hyaluronate intraperitoneal injection combined with oral Yanghe decoction in the treatment of knee osteoarthritis .Methods 80 patients with knee osteoar-thritis were randomly divided into two groups ,40 cases in each group .The control group was given intra -articular injection of sodium hyaluronate ,and the study group was treated with Yanghe decoction in addition .The TCM symptom score , knee joint index , overall treatment effect and quality of life were compared between the two groups .Results The total score of TCM symptoms after treatment in the study group was (7.08 ±1.18)points,which was significantly lower than (10.42 ±2.01)points in the control group(t=9.063,P<0.01).The VAS score and WOMAC score after treatment in the study group were (1.48 ±0.59)points,(19.10 ±3.08)points,respectively,which were significantly lower than (3.70 ±1.12)points and (23.40 ±3.56)points in the control group (t=11.091,5.777,all P<0.01). The HSS score after treatment in the study group was (83.04 ±10.49) points,which was significantly higher than (71.81 ±9.67)points in the control group(t =4.978,P<0.01).The physiological function,physical function, physical pain,mental health and energy scores after 6 months treatment in the study group were significantly higher than those in the control group (t=5.190,8.535,4.569,3.266,6.694,all P<0.01).The effective rate and total effective rate of the study group were 72.5％and 95.0％,respectively,which were significantly higher than those of the control group(50.0％,77.5％),the differences were statistically significant (χ2 =4.266,5.165,all P<0.05). Conclusion Sodium hyaluronate injection combined with oral Yanghe decoction is effective in the treatment of knee osteoarthritis.
ABSTRACT
Objective To observe the immune regulatory effect of Marasmius androsaceus (MA) polysaccharide in normal mice. Methods The experimental mouse was injected with high,middle,and low dosages of marasmius androsaceus polysaccharide(5,10,20 mg?kg-1?d-1) in the abdomen (i.p.) ,and the comparison group was given the same volume of saline water i.p. once a day. After treatment for 14 consecutive days,the blood cell count instrument was used to measure the mice hemogram,the phagocytic function of peritoneal macrophage and the ability of carbon granular clearance were observed.,the ability of the spleen lymphocytes proliferation was tested by MTT,and the hemolysin production test was used to evaluate the influence of MA polysaccharide on specific humoral immunity in mice. Results Marasmius androsaceus polysaccharide at middle and high dosages can increase the number of lymphocytes and moncytes in normal reference,enhance the phagocytic function of peritoneal macrophage,promote the carbon granular clearance,accelerate the proliferation of T lymphocyte,enhance the specific humoral imnune function. Conclusion Marasmius androsaceus polysaccharide has certain potentiating effect on the phagocytic function and immunity regulation.