ABSTRACT
<p><b>OBJECTIVE</b>To investigate the relationship between cerebral vasospasm and occurrence of delayed ischemic neurological deficit (DIND).</p><p><b>METHODS</b>The clinical records and radiographic images of 118 patients with subarachnoid hemorrhage admitted during last 5 years were reviewed. The incidence,degree and localization of cerebral vasospasm were evaluated, and morbidity of related DIND was analyzed. Patients with cerebral vasospasm were divided into three groups: Group MCA (middle cerebral artery), Group ACA (anterior cerebral artery) and Group ICA (intracranial carotid artery) according to the location of cerebral vasospasm. The consistency of DIND and image of cerebral infarction were examined.</p><p><b>RESULT</b>There was a weak correlation between cerebral vasospasm and incidence of DIND (r=0.22; P=0.016). The incidence of DIND was increased with severity of cerebral vasospasm (U=2.589, P<0.05). The group MCA had a significantly higher incidence of DIND than that of ACA and ICA groups (68.0% compared with 36.7% and 25.0%, respectively, chi(2)=8.195, P=0.004), the difference between later two groups was not statistically significant (chi(2)=0.646, P=0.421).</p><p><b>CONCLUSION</b>Cerebral vasospasm may be an important factor leading to DIND occurrence; the severity and location of cerebral vasospasm is related to the incidence of DIND.</p>
Subject(s)
Adult , Aged , Female , Humans , Male , Middle Aged , Aneurysm, Ruptured , Carotid Artery, Internal , Intracranial Aneurysm , Ischemic Attack, Transient , Rupture, Spontaneous , Subarachnoid Hemorrhage , Time Factors , Vasospasm, IntracranialABSTRACT
<p><b>OBJECTIVE</b>To investigate the distribution of G894T mutation of the endothelial nitric oxide synthase (eNOS) gene in Chinese Han nationality.</p><p><b>METHODS</b>G894T mutation of the eNOS gene of 108 unrelated healthy individuals was studied by means of polymerase chain reaction/restriction fragment length polymorphism (PCR-RFLP) analysis.</p><p><b>RESULT</b>All subjects were genotyped for eNOS gene; the frequencies of the GG, GT and TT genotypes were 0.9095, 0.0883 and 0.0021, respectively. In the Han nationality, the frequency of the GT, TT genotypes was lower than that in Japanese and Caucasian of UK (P< 0.05).</p><p><b>CONCLUSION</b>These results suggest that there are significant differences in G894T mutation of eNOS gene between the Chinese Han nationality and other ethnic populations.</p>