ABSTRACT
Objective To explore the clinical efficacy and safety of tetrandrine tablets and diclofenac sodium tablets in the treatment of osteoarthritis,thus to provide reference for the formulation of scientific and effective treatment.Methods From March 2015 to March 2016,Seventy patients with osteoarthritis in the People's Hospital of Yuyao were selected as study objects and divided into research group and control group according to the random number table method,with 35 cases in each group.The two groups were given glucosamine hydrochloride tablets treatment,the control group received diclofenac sodium tablets on the basis of treatment,while the research group received tetrandrine tablets on the basis of treatment of the control group,4 weeks for a course of treatment.The VAS score,joint tenderness index(TJS),joint swelling index (SJS),duration of morning stiffness,adverse reactions and clinical efficacy in the two groups were observed before and after treatment.Results The total effective rate in the study group was 97.14％ (34/35),which was higher than 80.00％ (28/35) in the control group,the difference was statistically significant between the two groups(x2 =23.932,P =0.001).Compared with before treatment,the VAS scores,SJS,TJS of the two groups were significantly decreased(all P ＜ 0.01).The study group compared with the control group,decreased more significantly,VAS score (t =6.78,P ＜ 0.05),SJS (t =5.78,P ＜ 0.05),TJS (t =6.65,P ＜ 0.05),and the morning stiffness time (t =6.98,P ＜ 0.05) were significantly reduced.The incidence rate of adverse reactions of the research group 5.71％ (2/35) was significantly lower than 31.43％ (11/35) of the control group(x2 =19.237,P ＜ 0.01).Conclusion Tetrandrine tablets combined with diclofenac sodium tablets in the treatment of osteoarthritis has low incidence of adverse reactions,high safety and ideal clinical effect,it can be widely used in clinical.
ABSTRACT
Objective To determine the incidence rate of HPV infection or multi-infections at different stages of cervical lesions in the development of cervical cancer , and the impact of specific types of HPV multi-infections on the risk of cervical cancer. Methods 103 samples of cervical tissues were detected and then divid-ed into ICC/HSIL group and LSIL/NILMF group according to the degree of pathological changes. HPV type was determined by PCR product sequencing. E6 nested multiplex PCR was performed to detect HPV multi-infections. Odds ratios were calculated to determinate the association between the sample category (LSIL/NILM or ICC/HSIL) and the specific types of HPV multi-infections. Results In HPV-positive samples, the rate of multi-in-fections had no significant differences between the two groups. Coinfection of HPV68 with HPV16 increased the risk of ICC/HSIL, as compared with HPV16 or HPV68 infection alone. Conclusions High-risk HPV coinfec-tions has a higher risk to induce ICC/HSIL than does HPV infection alone.
ABSTRACT
Objective The article aimed to investigate the correlation of lipid profile levels with deoxyribonucleic acid (DNA) damage and total antioxidant capacity (TAC) levels in obese pregnant women. Methods Healthy pregnant women (n=120 ) who took routine prenatal care from August 2011 to August 2012 in our hospital were recruited .All the pregnant women were di-vided into normal weight group ( n =45 ) and obese group ( n=75 ) .The lipid profile levels , DNA damage and TAC levels of two groups were compared and analyzed , and the correlations among lipid profile levels , DNA damage and TAC levels were analyzed . Results Compared to normal weight group , obese group showed significantly higher levels of TC (P=0.000), TG(P=0.000), and LDL-c(P=0.004), but a lower level of HDL-c (P=0.006).The DNA damage and TAC level of obese group were obviously higher than those of normal weight group (P=0.000, P=0.000).The DNA damage was positively correlated with levels of TC , TG and LDL-c among obese pregnant women (r=0.23, P=0.026;r=0.26, P=0.008;r=0.19, P=0.032), and TAC level was positive-ly correlated with TG level (r=0.32,P=0.000). Conclusion Dyslipidemia, imbalance of prooxidant and antioxidant status al-ways occur to obese pregnant women .The DNA damage is positively correlated with levels of TC , TG and LDL-c among obese pregnant women, and TAC is positively correlated with TG level .