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Objective To investigate the intervention effect of improved nursing measures in thoracoscopic laparoscopy combined with esophageal cancer resection. Methods Thirty patients with thoracoscopic and esophageal cancer resection who underwent routine nursing from June 2015 to June 2016 were selected as the control group. From July 2016 to July 2017, 34 patients with modified thoracoscopic and esophageal cancer resection were treated as study group. Time-related indicators, complication rate, preoperative anxiety, nursing satisfaction, and postoperative quality of life scores were observed. Results The time of extubation, the time of postoperative feeding, and the length of hospital stay were shorter in the study group than in the control group. The difference was statistically significant ( t=4.059, 2.490, 10.637, P<0.05). The total complication rate was lower in the study group (5.88％, 2/34) than in the control group (26.67％, 8/30), and the difference was statistically significant (χ2=5.222, P<0.05).The preoperative SAS anxiety score of the study group [(50.24±10.36) points] was lower than that of the control group [(67.31 ± 12.72) points], the nursing satisfaction [(96.82 ± 11.49) points], and the postoperative quality of life score [(80.03 ± 9.62) points] was higher than the control group [(80.03 ± 9.62) points, (77.45 ± 8.84) points], the difference was statistically significant (t=5.913, 6.290, 4.686, P<0.05). Conclusion Improved nursing measures can reduce the preoperative anxiety level of patients undergoing thoracoscopic and laparoscopic resection of esophageal cancer, improve nursing satisfaction, and help to speed up postoperative recovery and improve quality of life.
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To observe and analyze the therapeutic effect of combinated application of lobaplatin and irinotecan in treating recurrant small cell lung cancer. The 140 patients who were treated in our hospital for recurrant small cell lung cancer
were selected as research objects. All selected patients were subjected to combined application of obaplatin and irinotecan, the total therapeutic effect was observed, and the adverse reactions occurring during treatment were recorded.
Through observing the total treatment effective ratio of 140 patients recurrant small cell lung cancer, the number of complete remission cases, number of partial remission cases, number of stable disease cases, and number of disease
progression cases were 40[28.57%], 28[20.00%], 30[21.43%], 42[30.00%], respectively, with total effective ratio of 48.57%. The average time to progression [TTP] was [4.5±0.8] months, average overall survival [OS] was [7.6+/-1.2]
months. The toxic and adverse effects mainly included hematological toxicity and gastrointestinal adverse reaction, such as leukocyte reduction, neutrophil reduction, thrombocytopenia, decreased hemoglobin, nausea and vomiting, diarrhea. No toxicity-related death occurred. In treatment of patients with recurrant small cell lung cancer, the combined application of lobaplatin and irinotecan can achieve great results, which is a safe and reliable way of treatment
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Objective To investigate the relationship between serum tumor markers and the severity of silicosis.Methods Retrospective study.Total of 160 patients with silicosis were included in the study, and 160 healthy volunteers were recruited as the control group.Tumor marker levels in both bronchoalveolar lavage fluid(BALF)and serum were detected by the immunochemiluminecence methods.The pulmonary function parameters, blood gas analysis and lactate dehydrogenase(LDH)were also analyzed.Lung tissue obtained by a patient with silicosis was stained by neuron specific enolase(NSE), carbohydrate antigen125(CA125) and carbohydrate antigen19-9(CA19-9).Results Serum NSE, CA125 and CA19-9 levels were significantly higher in cases than those in controls[(34.47±13.30)μg/L vs(10.24±7.20)μg/L,t=20.27, P<0.000 1;(33.96±17.80)kU/L vs(12.23±15.30)kU/L, t=11.71, P<0.000 1;(4.68±5.67)kU/L vs(2.78±3.45)kU/L,t=3.67,P<0.002].Significant negative correlations were found between values of tumor markers(CA125 and CA19-9) and spirometric parameters,such as forced expiratory volume in one second %(FVE1%), forced expiratory volume in one second/forced vital capacity(FVE1/FVC), carbon monoxide diffusion capacity (Dlco) and total lung capacity(TLC) (r=-0.423,P=0.001;r=-0.323,P=0.011;r=-0.479,P=0.001;r=-0.285,P=0.043) and (r=-0.324,P=0.022;r=-0.256,P=0.023;r=-0.354,P=0.013;r=-0.356,P=0.012).Significant positive correlations were also observed between values of these tumor markers and LDH(r=0.378,P=0.001 and r=0.347,P=0.21).Significant negative correlations were found between NSE and Dlco and TLC(r=-0.374,P=0.004 and r=-0.368,P=0.002).Significant positive correlations were also observed between NSE and LDH(r=0.404,P=0.001).The NSE and CA19-9 levels in BALF were significantly higher than those in serum[(39.32±29.30)μg/L vs(25.7±12.12)μg/L,t=2.15,P=0.036;(21.36±12.11)kU/L vs(11.28±10.78)kU/L, t=2.64,P=0.012].Patients experienced a decrease in NSE and CA19-9 concentrations following whole lung lavage[(39.20±10.24)μg/L vs(15.32±8.35)μg/L,t=8.02,P<0.05;(26.24±12.23)kU/L vs(18.84±5.64)kU/L,t=2.46,P<0.05].Immunohistochemical studies showed positive NSE and CA19-9 staining in lung biopsy specimen.Conclusion Elevated serum tumor markers including NSE, CA125 and CA19-9 would provide valuable clinical information to assess disease severity in silicosis.
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Objective To study the early expression of ca]pain Ⅱ and microtubule associated protein 2 (MAP2) mRNA in the hippocampus of the lateral fluid percussion injury rats. Methods 18 Male Sprague-Dawley rats were randomly divided into 3 groups. The changes of Calpaln Ⅱ and MAP2 mRNA in hippocampus 3 h after injury were detected by real-time PCR. Results Compared to the control group (n = 6), the expression for Ca]pain Ⅱ mRNA increased obviously(P <0.01)in the lateral fluid percussion injury group(n=6) ,the expression for MAP2 mRNA degraded obviously(P <0.01). Compared with the lateral fluid percussion injury group(n =6) ,the expression for calpuin Ⅱ mRNA in the mild hypothermia group degraded obviously (n = 6), the expression for MAP2 mRNA increased obviously(P <0.01). Conclusion Mild hypothermia may act as neuroprotection by inhibiting the expression of Ca]pain Ⅱ and easing the degradation of cytoskeleton.
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Objective Improve sugar coating and finished product stability to be fit for users. Method Adopt new technology of film coating to substitute for sugar coating. Result The finished products which adopt the film coating technology are better to resolve original questions there are some spots on finished products surface and are not fit for some people to use. Reduce dosage of anti-activities and shorten disintegration time, improve products quantity and stability. Conclusion The film coating method is simple and ideal, which is good for application.