ABSTRACT
Human carboxylesterase 1 (HCE1), belonging to a multigene serine hydrolase family, is a major liver carboxylesterase responsible for the hydrolysis and metabolism of various xenobiotics. It also plays an important role in the transportation and metabolism of endogenous cholesterol ester and free fatty acid, and is closely associated with the pathogenesis of hepatocellular carcinoma. This review describes current developments in the molecular structure, the roles in drug, toxins and lipid metabolism, and the early diagnosis for hepatocellular carcinoma of human carboxylesterase 1.
Subject(s)
Humans , Carboxylic Ester Hydrolases , Genetics , Physiology , Carcinoma, Hepatocellular , Diagnosis , Cholesterol Esters , Metabolism , Fatty Acids, Nonesterified , Metabolism , Liver Neoplasms , Diagnosis , Xenobiotics , MetabolismABSTRACT
Objective To explore the main influence factors of ederly people's cognitive function and provide the countermeasures. Methods A cross-sectional study was performed in the elderly volunteers who were sampled from halves of the counties of 22 provinces in China.Modified minimental state examination(MMSE)scale was adopted to investigate the 6819 Chinese elderly people who were investigated in the Chinese elderly health questionnaire in 2002.Simple Chi-square test and multiple logistic regressions were applied in the analysis. Results The results showed that the perfect rate of cognition function was 85.0%in male,and 80.43%in female.The rate was 97.7%in people at age of 60-69 years,94.8%,70-79 years,85.0%,80-89 years,71.11%,90-99 years,55.7%,100-111 years,94.8%.There existed significant cognitive function differences in gender,age,education,born place,marital status,1iving status,smoking history,drinking history,physical exercise,self-satisfaction with life,affective state and healthy status(all P＜0.01).Non-conditional logistic regression analysis showed that influence factors of cognitive function of the elderly were age,education level,marital status,physical exercise and optimistic state. Conclusions The risk factors for cognitive function are aging and widowhood.Higher education,regular physical exercise,optimistic state are protective factors for cognitive function.
ABSTRACT
Objective To investigate the risk factors for respiratory failure in infants with severe pneumonia aged 1～36 months in order to reduce the mortality of inpatients with severe pneumonia Methods Prospective study were conducted on the collected 567 inpatient infants suffering from severe pneumonia from July 1,2000 to June 30,2001 in randomized selected 13 hospitals in Hunan 17 factors were surveyed and analyzed depending on curative effect ( with respiratory failure or without respiratory failure) as variable by single logistic regression and multiple logistic regression Results Single logistic regression analysis indicated that rachitis,congenital heart disease,hemaglobulin,frequently cold,diettherapy,season,evaluation severity score were risk factors relevant to respiratory failure in severe pneumonia Multiple logistic regression analysis indicated that innutrition,hemoglobulin,rachitis,frequently cold,season,evaluation severity score were risk factors associated with respiratory failure in severe pneumonia Conclusion Innutrition,hemoglobulin,rachitis,frequently cold,season,evaluation severity score are risk factors associated with respiratory failure in severe pneumonia