PHARMACOKINETICES OF RANITIDINE IN NORMAL SUBJECTS / 重庆医科大学学报

The pharmacokinetics of ranitidine was studied with the method of high performance li-quid chromatography in 10 healthy volunteers. The subjects were given a single dose of ranitidine 150mg (one capsule) orally. The serum concentration-time curves showed that one-compartment open model could be used in all subjects. The equation of mean serum conccentration was and with following pharmacokinetic parameters: (hr), and There were no statistically significant differences between the, kinetic parameters of reported articles and ours