ABSTRACT
OBJECTIVE@#To investigate the relationship between serum brain-derived neurotrophic factor, concentrations and BDNF gene Val66Met polymorphism and amnestic mild cognitive impairment (aMCI), and neuropsychological characteristics.@*METHODS@#Ninety-nine aMCI patients and 99 matched normal controls were recruited for the study. Multi-dimension neuropsychologic tests were used to extensively assess the cognitive function, an enzyme-linked immunosorbent assay was applied to measure serum BDNF concentrations, and polymerase chain reaction-restriction fragment length polymorphism was used to analyse BDNF gene Val66Met polymorphism in the subjects.@*RESULTS@#The scores of neuropsychologic tests in aMCI patients were significantly lower than those in the normal controls (all P0.05).@*CONCLUSION@#aMCI is characterized by episodic memory impairment. Decreased BDNF concentrations may play a role in the pathophysiology of aMCI, and BDNF gene Val66Met polymorphism may not be an important genetic factor in susceptibility to aMCI.
Subject(s)
Aged , Aged, 80 and over , Female , Humans , Male , Alzheimer Disease , Genetics , Amnesia , Blood , Genetics , Brain-Derived Neurotrophic Factor , Blood , Genetics , Cognition Disorders , Blood , Genetics , Methionine , Genetics , Polymorphism, Genetic , Genetics , Valine , GeneticsABSTRACT
<p><b>OBJECTIVE</b>To find a good way to diagnose VD, value the effect of Yishen Yangnao capsule on VD and try to find some rules of changes in Chinese medicine syndromes.</p><p><b>METHOD</b>Patients were randomly divided into treating group and western medicine comparison group. It's the phase III clinical research of Rishen Yangnao capsule curing VD, judging the validity and security of it, using dukexi slice as comparison drug. Some of the patients did the examination of P300.</p><p><b>RESULT</b>The total validity of Yishen Yangnao capsule is 56.3% (contract team is 60.0%). The improve rate of ADL is 0.1069% (contract team is 0.1134%). The scores of Chinese medicine syndrome descend.</p><p><b>CONCLUSION</b>Yishen Yangnao capsule has the same effect as dukexi slice in curing VD at the side of intelligence situation and life ability.</p>