ABSTRACT
Objective@#To explore the association between interaction effects of dietary behaviors and caregivers s type on overweight or obesity among left-behind children, and to provide a reference for overweight or obesity prevention among the left-behind children.@*Methods@#From October to December 2018, 877 left-behind children aged 7-18 years were randomly selected from a stratified cluster in county, Shangrao City, Jiangxi Province.Type of caregives, dietary behavior, health status were collected from questionnaires, height, weight were examined.@*Results@#The detection rate of overweight and obesity in left-behind children was 21.7%(190/877), and the rate of overweight and obese left-behind children with other foster parents was 29.8%(158/530), higher than the rate of 16.2%(32/198). The detection rate of overweight and obesity of left-behind children who consumed high level of western fast food was 59.0%(59/100). There were significant differences in rate of overweight and obesity by type of caregiver and western food consumption. Regression analysis showed that the detection rate of overweight and obesity of left-behind children who often ate western fast food was 5.70 times(95%CI=3.62-8.99) high than that of those who seldom ate western fast food. Interaction analysis showed that the interaction(synergistic effect) of the type of adopter × whether the adopter often ate western fast food(father or mother × yes) presents a positive multiplying interaction(synergistic effect). Left-behind children under paternal or maternal care together with high western fast food consumption greatly increased the risk of overweight and obesity(OR=6.94, 95%CI=2.76-17.44).@*Conclusion@#Frequent consumption of western fast food together with one parent stay at home is associated with overweight and obesity of left-behind children. These two factors have a synergistic effect, which greatly increases the risk of overweight and obesity of left-behind children. In other words, their interaction is a major risk factor.
ABSTRACT
Objective To investigate the relationship between leptin level of IGR patients and intima-media thickness (IMT) of carotid arterial. Methods One hundred and eighteen IGR patents were enrolled into the following three groups according to the result of oral glucose tolerance test (OGTT): 38 cases of the purely impaired fasting glucose (IFG) group, 42 cases of the purely impaired glucose tolerance (IGT) group and 42 cases of the IFG combining with IGT (IFG + IGT) group. Thirty-eight cases with normol glucose tolerance (NGR) were enrolled in the NGR group. The blood fat, fasting blood-glucose (FBG), fasting insulin (insulin), fasting C peptide , 2 h-postprandial blood glucose , 2 h-insulin , 2 h-C peptide , glycosylated hemoglobin (HbA1C), C-reactive protein (CRP), body mass index (BMI), leptin and IMT were determined in patients of the three groups and the healthy controls. The multiple linear regression was used to analyze the relationship between leptin level and IMT , and person correlation was further used to analyze the affinity degree between leptin level and IMT. Results Compared with the NGT group, the inter-group comparison showed that leptin level was significantly increased in the IFG, IGT and (IFG + IGT) groups (P < 0.05, respectively). Compared with the IFG and IGT groups, IMT and the leptin level were increased in the (IFG + IGT) group (P < 0.05, respectively). The multiple linear regression analysis showed that leptin level was correlated with the increase of IMT in the (IFG + IGT) group (P < 0.05), but not in the IFT group and the IGT group. Conclusion The leptin level in the IGR group and the IMT in the IFG + IGT ) group were significantly increased , the leptin level was closely associated with IMT.
ABSTRACT
Comorbid depression and chronic pain are highly prevalent in individuals suffering from physical illness .Here, we critically examine that inflammation is the possible mechanism of comorbidity of pain and depression .These mechanisms include direct effects of cytokines on the neuronal environment or indirect effects via downregulation of G protein -coupled receptor kinase 2, activation of the tryptophan-degrading enzyme indoleamine 2,3-dioxygenase that generates toxic kynurenine metabolites .We review the role of in-flammation in the mechanism of the commorbidity of depression and pain .