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Objective To evaluate the efficacy and safety of deoxyribonucleotide natrium in the treatment of secondary pulmonary tuberculosis.Methods A total of 94 cases with secondary pulmonary tuberculosis included in this study were dividing into control group and experiment group with each 47 cases.The patients in the both groups were give regular treatment.Patients in the control group were given standard chemotherapy regimen 3HRES/3HRE and patients in the experiment group revieved sodium deoxyribonucleotide injection 150mL+5％injection of liquid glucose 250mL by intravenous drip with once a day.1 time/d,two groups of patients with a cycle of 28d,a total of one cycles of treatment.The clinical efficacy,CA125,CA199,function of liver and kidney,occurrence of adverse reactions were compared between the two groups.Results The clinical efficacy in experiment group was 94.44％,which significant higher than that in control group 75.00％(P<0.05).The serum level of CA125 and CA199 decreased after treatment with experiment group much lower than the control group(P<0.05).Compared with the control group,the ALT,AST,Cr and serum BUN levels before and after treatment,the difference was not statistically significant.The adverse drug reactions was not statistically different between the two groups.Conclusion Deoxyribonucleotide natrium in the treatment of secondary pulmonary tuberculosis was effective with high safety.
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Objective:To investigate the effect of salvia miltiorrhiza phenolic acid combined with ulinastatin in the treatment of a-cute respiratory distress syndrome ( ARDS) and the influence on the biochemical parameters of patients. Methods:Totally 86 cases of ARDS were selected and randomly divided into the observation group (43 cases) and the control group (43 cases) according to the random number table. The control group was treated with the routine treatment, and the observation group was treated with salvia milti-orrhiza phenolic and injection additionally. The treatment course was 10 days. The total effective rate, RR and HR, PaO2 , SaO2 and PaCO2 , IL-6, TNF-αand CRP levels and the incidence of adverse reactions were compared between the groups. Results:The total ef-fective rate of the observation group(86. 05%) was higher than that of the control group (67. 44%, P<0. 05). RR and HR in the two groups were significantly decreased after the treatment (P<0. 05), and those in the observation group were significantly lower than those in the control group (P<0. 05). After the treatment, PaO2and SaO2 were significantly increased in the two groups, and PaCO2 was significantly decreased (P<0. 05), and SaO2 and PaO2 in the observation group were higher than those in the control group, and PaCO2 was lower than that in the control group (P<0. 05). The plasma levels of IL-6, TNF-α and CRP were significantly decreased in the two groups after the treatment (P<0. 05), and those in the observation group were lower than those in the control group (P<0. 05). No serious adverse drug reactions were found in the two groups. Conclusion:The effect of salvia miltiorrhiza phenolic acid in the treatment of ARDS is significant, and it can significantly improve heart rate, respiratory rate, blood gas and serum inflammatory factors, which is worthy of promoted clinical application.
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Objective:To investigate the effect of meglumine adenosine cyclophosphate combined with Shenmai injection on the balance of Th1/Th2 cells in the patients with bronchial asthma. Methods:Totally 75 cases of patients with bronchial asthma were ran-domly divided into the treatment group (38 cases) and the control group (37 cases). The control group was treated with the conven-tional therapy, while the treatment group was treated with meglumine adenosine cyclophosphate combined with Shenmai injection by in-travenous infusion additionally for 14 days. The level of Th1/Th2 cells was detected by flow cytometry, and the serum level of IL-10, IL-4 and IFN-γ was detected by enzyme-linked immunosorbent assay ( ELISA) before and after the treatment, and the clinical thera-peutic effect was assessed. Results:①Compared with that before the treatment, the expression level of Th1, Th1/Th2 and IFN-γwas increased in both groups, while the expression level of IL-4 and IL-10 was decreased after the treatment, and the changes in the treat-ment group were more notable than those in the control group (P0. 05). ②The clinical efficiency of the treatment group was 94. 74%, while that of the control group was 83. 78%. The curative effect of the treatment group was better than that of the control group (P<0. 05). Conclusion:Meglumine adenosine cyclophosphate combined with Shenmai injection shows definitely clinical curative effect on bronchial asthma, and the mechanism may be related with regulating the imbalance expression level of Th1/Th2 and inflammatory cytokines.