Correlation Analysis of Tear Film Lipid Layer Thickness and Ocular Surface Disease Index

PURPOSE: To analyze the relationship between ocular surface disease index and tear film lipid layer thickness (LLT) using a LipiView II® (LipiView® Ocular Surface Interferometer, TearScience®, Morrisville, NC, USA) interferometer. METHODS: Forty-nine patients diagnosed with dry eye syndrome were recruited for this prospective study. Patients completed ocular surface disease index questionnaires. We performed slit lamp examination, Schirmer test, corneal and conjunctival fluorescein staining, measured tear film break-up time, and graded meibomian gland dysfunction. Tear LLT, blinking time, and dynamic meibomian imaging were analyzed using a LipiView II® ocular interferometer. To control for missing data, we analyzed four sets of imputated data via the multiple imputation method and performed Pearson correlation analysis. Patients were assigned to one of two LLT categories (LLT < 60 or LLT ≥ 60) and Chi-square test was performed. RESULTS: Among ocular surface disease parameters, tear film break-up time (tBUT) had a statistically significant correlation with average and maximum LLT (average LLT; p = 0.008, 0.035, 0.006, 0.049, maximum LLT; p = 0.006, 0.042, 0.020, 0.049, Pearson correlation analysis with multiple imputation) but there was no significant correlation with minimum LLT (minimum LLT; p = 0.048, 0.090, 0.079, 0.039). Of the patients with a relatively thick average LLT or maximum LLT (LLT ≥ 60 nm), 80% and 88% had a tBUT < 10, respectively. Conversely, 39% and 47% of patients with relatively thin average LLT (LLT < 60 nm) had a tBUT < 10 (average LLT; p = 0.013, maximum LLT; p = 0.039). CONCLUSIONS: Average LLT and maximum LLT were significantly correlated with tBUT. Patients with a relatively thin average or maximum LLT tended to have a shorter tBUT. Based on these results, measuring tear film LLT using a LipiView II® interferometer may be useful in the diagnosis and follow-up of patients with evaporative dry eye.

Comparison of Short-term Clinical Outcomes between Scleral Fixation vs. Iris Fixation of Dislocated IOL

PURPOSE: To compare clinical outcomes between iris fixation and scleral fixation as treatments for dislocated Intra Ocular Lens. METHODS: Ten eyes of 10 patients underwent scleral fixation (scleral fixation group) and 8 eyes of 8 patients underwent iris fixation (iris fixation group) were enrolled in this retrospective study. In each group, visual acuity and intra ocular pressure, slit lamp examination, fundus examination, refraction, keratometry, axial length and anterior chamber depth were measured before the surgery. Regular follow up was made 1 day, 1 week, 1 month, and 2 months after surgery and visual acuity, intra ocular pressure, slit lamp exam, refractory error, anterior chamber depth, intraocular lens (IOL) tilting, and decentration were measured at each visit. RESULTS: There were no significant differences in uncorrected visual acuity (UCVA), best corrected visual acuity (BCVA), and refractive error for patients with iris and scleral fixation before and after surgery. Patients with iris fixation had significantly deeper anterior chamber depth (ACD) and more IOL tilting than patients with scleral fixation. CONCLUSIONS: In this study, the iris fixation group tended to have more IOL tilting and deepening of anterior chamber depth than the scleral fixation group. We can use this information to choose the appropriate surgical method for dislocated IOL and to select of new IOL.

Comparison of Short-term Clinical Outcomes between Scleral Fixation vs. Iris Fixation of Dislocated IOL

PURPOSE: To compare clinical outcomes between iris fixation and scleral fixation as treatments for dislocated Intra Ocular Lens. METHODS: Ten eyes of 10 patients underwent scleral fixation (scleral fixation group) and 8 eyes of 8 patients underwent iris fixation (iris fixation group) were enrolled in this retrospective study. In each group, visual acuity and intra ocular pressure, slit lamp examination, fundus examination, refraction, keratometry, axial length and anterior chamber depth were measured before the surgery. Regular follow up was made 1 day, 1 week, 1 month, and 2 months after surgery and visual acuity, intra ocular pressure, slit lamp exam, refractory error, anterior chamber depth, intraocular lens (IOL) tilting, and decentration were measured at each visit. RESULTS: There were no significant differences in uncorrected visual acuity (UCVA), best corrected visual acuity (BCVA), and refractive error for patients with iris and scleral fixation before and after surgery. Patients with iris fixation had significantly deeper anterior chamber depth (ACD) and more IOL tilting than patients with scleral fixation. CONCLUSIONS: In this study, the iris fixation group tended to have more IOL tilting and deepening of anterior chamber depth than the scleral fixation group. We can use this information to choose the appropriate surgical method for dislocated IOL and to select of new IOL.

Age-related Changes in Anterior, Posterior Corneal Astigmatism in a Korean Population

PURPOSE: To evaluate age-related changes in anterior and posterior corneal astigmatism in Koreans. METHODS: The anterior and posterior corneal astigmatisms of 160 subjects with age ranging from 11 to 92 years, none of whom experienced any complications, were measured with a rotating Scheimpflug camera (Pentacam®). Using this data, the changing proportions of with-the-rule to against-the-rule and changing tendency of anterior and posterior corneal astigmatisms with age were evaluated using polar value analysis according to the Naeser method. RESULTS: For the anterior cornea, the proportion of with-the-rule astigmatisms decreased with age (p < 0.0001). On the other hand, for the posterior cornea, the proportion of against-the-rule astigmatisms decreased with age (p = 0.012). In the polar value analysis, there was a trend toward against-the-rule astigmatism associated with increasing age for the anterior cornea (p < 0.0001) and toward with-the-rule astigmatism for the posterior cornea (p < 0.0001). CONCLUSIONS: In previous studies, the anterior corneal surface shifted from with-the-rule to against-the-rule astigmatism with increasing age, whereas the posterior corneal surface remained as against-the-rule astigmatism in most cases. But, our results showed that the proportion of against-the-rule astigmatisms of the posterior cornea decreased with age. Thus, evaluation of posterior corneal astigmatisms should be performed before cataract surgery in old patients, especially when using a multifocal or toric intraocular lens.

Analysis of Changes in Anterior, Posterior and Total Corneal Astigmatism after On-Axis Cataract Surgery

PURPOSE: To assess the changes in anterior, posterior, and total corneal astigmatism after cataract surgery with on-axis clear corneal incision cataract surgery. METHODS: This study included 48 eyes (24 eyes with 'with-the-rule [WTR]' and 24 eyes with 'against-the-rule [ATR]') that underwent phacoemulsification and intraocular lens insertion through on-axis clear corneal incision. The ATR group with vertically steep axis of posterior corneal astigmatism was divided into subgroups 1 and 2 for the opposite axis. Autorefraction, uncorrected and best-corrected visual acuities were measured. Corneal astigmatism (anterior, posterior and total) was measured using Pentacam(R) preoperatively and 1 week, 1 month, and 2 months postoperatively. RESULTS: Multivariate linear regression analysis of preoperative data showed positive correlations among anterior, posterior and total astigmatism. Anterior corneal astigmatism showed a significant decrease in both WTR and ATR groups in all measured points (all p 0.05) and significant decrease in the ATR subgroup 1 (p 0.05). According to correlation analysis based on trend line equations, 1.7 diopters of anterior astigmatism could expect 0.3 diopters of posterior astigmatism and 0.5 diopters of total astigmatism for the WTR group and 0.4 diopters of anterior astigmatism could expect 0.2 diopters of posterior astigmatism and 0.4 diopters of total astigmatism for the ATR group. CONCLUSIONS: Considering the majority of cataract patients have vertically steep posterior corneal astigmatism, temporal incision for ATR patients is generally effective. Moreover, for patients with WTR astigmatism of more than 1.7 diopters or ATR astigmatism greater than 0.8 diopters, additional preoperative correction based on posterior astigmatism is needed for more precise prediction of postoperative total corneal astigmatism.

Surgically Induced Posterior Corneal Astigmatism in 2.2 mm Microcoaxial Cataract Surgery Versus 2.85 mm Coaxial Conventional Cataract Surgery

PURPOSE: To compare the surgically induced posterior astigmatism of microcoaxial cataract surgery using a 2.2 mm incision and conventional cataract surgery using a 2.85 mm incision. METHODS: This study included 56 eyes that underwent phacoemulsification and intraocular lens insertion. Subjects were divided into 2 groups: 26 eyes receiving a microcoaxial cataract surgery using a 2.2 mm incision (MCCS group) and 30 eyes receiving a conventional cataract surgery using a 2.85 mm incision (CCS group). Anterior, posterior and total corneal astigmatism was measured. The surgically induced anterior astigmatism, surgically induced posterior astigmatism and surgically induced total astigmatism were compared between MCCS and CCS groups. Corneal astigmatism was measured using a Pentacam(R) device (Oculus, Wetzlar, Germany), uncorrected visual acuity, best corrected visual acuity and corneal aberrations of front and rear side was measured preoperatively and at 1 day, 1 month and 2 months postoperatively. RESULTS: There was no difference in surgically induced posterior astigmatism between CCS and MCCS groups, however, surgically induced anterior astigmatism and surgically induced total astigmatism were significantly lower in the MCCS group than in the CCS group (p = 0.005 and, p = 0.036, respectively). There was a significant positive linear correlation between surgically induced posterior astigmatism and surgically induced total astigmatism in the CCS group (p = 0.01, r = 0.563). There was also a significant positive linear correlation between surgically induced anterior astigmatism and surgically induced total astigmatism in both CCS and MCCS groups (CCS group: p = 0.00, r = 0.855; MCCS group: p = 0.039, r = 0.407). CONCLUSIONS: There was no significant difference in the surgically induced posterior astigmatism between the MCCS and CCS groups. However, surgically induced posterior astigmatism significantly affected surgically induced total astigmatism in the CCS group but not in the MCCS group. Considering both anterior and posterior astigmatism of the cornea, microcoaxial cataract surgery using a 2.2 mm incision affects surgically induced total astigmatism less than conventional cataract surgery.

Assessment of Posterior Capsular Opacification of Korean Using Straylight and Glare Sensitivity Meter

PURPOSE: To evaluate posterior capsular opacity (PCO) using straylight and glare sensitivity meter and to compare availability of straylight and glare sensitivity with known methods for PCO evaluation. METHODS: Thirty-six pseudophakic eyes with PCO were selected for this study. Best-corrected visual acuity (BCVA), straylight (C-quant, Oculus GmbH, Wetzlar, Germany) and glare sensitivity (Binoptometer, Oculus GmbH, Wetzlar, Germany) were measured before mydriasis. After mydriasis, PCO images were captured with a slit-lamp and analyzed using the Evaluation of Posterior Capsular Opacification (EPCO) program (EPCO software, University of Heidelberg, Heidelberg, Germany). The same measurements were taken after capsulotomy and compared with pre-capsulotomy data. RESULTS: After capsulotomy, BCVA, EPCO score and straylight were improved with statistical significance (p < 0.05). Cases of PCO with mildly decreased visual acuity showed statistically significantly improved EPCO score and straylight (p < 0.05). Glare sensitivity did not show significant improvement but was statistically significantly correlated with straylight (p = 0.023, Rho = 0.732). CONCLUSIONS: Straylight is an available measurement for evaluation of PCO. Glare sensitivity meter which correlates with straylight can be used as a supportive measurement.

Assessment of Posterior Capsular Opacification of Korean Using Straylight and Glare Sensitivity Meter

PURPOSE: To evaluate posterior capsular opacity (PCO) using straylight and glare sensitivity meter and to compare availability of straylight and glare sensitivity with known methods for PCO evaluation. METHODS: Thirty-six pseudophakic eyes with PCO were selected for this study. Best-corrected visual acuity (BCVA), straylight (C-quant, Oculus GmbH, Wetzlar, Germany) and glare sensitivity (Binoptometer, Oculus GmbH, Wetzlar, Germany) were measured before mydriasis. After mydriasis, PCO images were captured with a slit-lamp and analyzed using the Evaluation of Posterior Capsular Opacification (EPCO) program (EPCO software, University of Heidelberg, Heidelberg, Germany). The same measurements were taken after capsulotomy and compared with pre-capsulotomy data. RESULTS: After capsulotomy, BCVA, EPCO score and straylight were improved with statistical significance (p < 0.05). Cases of PCO with mildly decreased visual acuity showed statistically significantly improved EPCO score and straylight (p < 0.05). Glare sensitivity did not show significant improvement but was statistically significantly correlated with straylight (p = 0.023, Rho = 0.732). CONCLUSIONS: Straylight is an available measurement for evaluation of PCO. Glare sensitivity meter which correlates with straylight can be used as a supportive measurement.

The Change in Corneal Astigmatism after Cataract Surgery in Patients with Small Amount of Astigmatism

PURPOSE: To analyze the change in posterior corneal astigmatism and total corneal astigmatism in patients with anterior corneal astigmatism less than 1.0 diopter (D). METHODS: In the present study we evaluated 52 eyes with anterior corneal astigmatism less than 1.0 D. Patients were divided into 2 groups according to steep axis: Group 1 included 33 eyes with within-the-rule (WTR) astigmatism and Group 2 included 19 eyes with against-the-rule (ATR) astigmatism. Anterior, posterior and total corneal astigmatism were measured using Scheimpflug imaging (Pentacam(R)). RESULTS: In Group 1, preoperative anterior astigmatism, posterior astigmatism and total astigmatism were 0.55 +/- 0.44 D, 0.31 +/- 0.14 D and 0.30 +/- 0.72 D, respectively. At postoperative 2 months, anterior astigmatism, posterior astigmatism and total astigmatism were 0.51 +/- 0.67 D, 0.31 +/- 0.15 D and 0.35 +/- 0.81 D, respectively. There was no statistically significant difference between preoperative and postoperative anterior, posterior and total corneal astigmatism in Group 1. In Group 2, preoperative anterior astigmatism, posterior astigmatism and total astigmatism were -0.48 +/- 0.46 D, 0.26 +/- 0.09 D and -0.51 +/- 0.65 D, respectively. At postoperative 2 months, anterior astigmatism, posterior astigmatism and total astigmatism were -0.17 +/- 0.68 D, 0.25 +/- 0.13 D and -0.30 +/- 0.55 D, respectively. There was no statistically significant difference between preoperative and postoperative anterior, posterior and total corneal astigmatism in the 2 groups. There was no statistical correlation between preoperative posterior corneal astigmatism and postoperative 2 months total corneal astigmatism. After vector analysis, surgically induced astigmatism (SIA) of the anterior and total astigmatism in Group 1 were 0.03 D @ 30degrees and 0.07 D @ 74degrees, respectively, and in Group 2 were 0.27 D @ 100degrees and 0.36 D @ 86degrees, respectively. CONCLUSIONS: In patients with preoperative total corneal astigmatism less than 1.0 D, posterior corneal astigmatism had a small effect on postoperative total corneal astigmatism.

Refractive Change after Transscleral Fixation of Intraocular Lens

PURPOSE: To evaluate the anterior chamber depth (ACD), extent of intraocular lens (IOL) tilt, and decentration and refractive error after transscleral fixation of IOL. METHODS: We retrospectively reviewed the medical records of 17 cases with transscleral fixation of IOL (6 with aphakia, 5 with IOL dislocation, and 6 with lens subluxation). The acrylic IOL (MN60AC(R)) was fixated in 12 eyes and the polymethylmethacrylate IOL (CZ70BD(R)) was fixated in 5 eyes at 1.0 mm posterior from the limbus. We analyzed the ACD, extent of IOL tilt and decentration, manifest refraction, refractive error, higher order aberration, and corneal endothelium at 2 weeks, 1 month and 2 months postoperatively. RESULTS: The mean ACD was 3.36 +/- 0.11 mm, 3.30 +/- 0.12 mm, and 3.27 +/- 0.13 mm, the mean extent of IOL tilt was 4.61 +/- 0.12degrees, 4.65 +/- 0.14degrees, and 4.60 +/- 0.12degrees and the mean extent of IOL decentration was 0.43 +/- 0.01 mm, 0.45 +/- 0.01 mm, and 0.45 +/- 0.01 mm at 2 weeks, 1 month and 2 months postoperatively, respectively in eyes with transscleral fixation of IOL. The ACD was shallower and the extent of IOL tilt and decentration was greater than with IOL in-the-bag insertion patients. The mean refractive errors were -0.55 +/- 0.27 D, -0.63 +/- 0.24 D, and -0.69 +/- 0.19 D at the same period, respectively. CONCLUSIONS: Although postoperative refractive error is influenced by surgeon factors such as incision size, distance of fixation suture from limbus, and tightness of suture material, according to our results, an IOL 0.75 D more hyperopic than predicted should be selected in transscleral fixation of IOL at 1.0 mm posterior from the limbus. Additionally, each surgeon should assess their specific results and modify the lens calculations accordingly.

Comparative Study of Clinical Outcomes Between 2 Types of Multifocal Aspheric Intraocular Lenses

PURPOSE: To evaluate the efficacy of the OptiVis(TM) Multifocal intraocular lens (IOL) and compare the clinical outcome between OptiVis(TM) and AcrySof(R) ReSTOR(R) D1. METHODS: We reviewed 20 eyes of 11 patients implanted with OptiVis(TM) and 20 eyes of 10 patients implanted with AcrySof(R) ReSTOR(R) D1. The clinical outcomes of the 2 IOLs were evaluated 1 and 2 months postoperatively and consisted of distant, intermediate, and near visual acuity, depth of focus, contrast sensitivity, wavefront aberration, patient satisfaction, decentration and IOL tilt. RESULTS: Intermediate vision was better in the OptiVis(TM) group. There were no statistical differences between the 2 groups with respect to distant vision, near vision and wavefront aberration, contrast sensitivity, decentration and IOL tilt. Depth of focus was deeper in the OptiVis(TM) group at the intermediate visual acuity zone. There were no statistically significant result differences between postoperative 1 and 2 months. CONCLUSIONS: The OptiVis(TM) multifocal IOL provided satisfactory visual acuity at distance, near, and intermediate with no apparent reduction in contrast sensitivity. The IOL can be effective for improving patient satisfaction after cataract surgery as well as correcting presbyopia.

A Case of Congenital Monocular Elevation Deficiency Associated with Inferior Rectus Anomaly

PURPOSE: To report a congenital monocular elevation deficiency (MED) associated with inferior rectus anomaly. CASE SUMMARY: A 3-year-old, otherwise healthy boy presented with left hypotropia. He showed chin-up and left head turn with left pseudoptosis. On examination, there was a left hypertropia of 60 prism diopters (PD) and esotropia in primary position. Upgaze -4 limitation in abduction and -3 from primary position, poor Bell's phenomenon, and normal vertical saccadic velocity until midline were observed. On orbital CT, thin and nasally displaced left inferior rectus showing enlargement at its posterior segments near the orbital apex was observed. Forced duction test at surgery revealed a strong positive restriction and thin, taut, fibrotic inferior rectus was inserted and displaced nasally. CONCLUSIONS: Left inferior rectus recession of 5.5 mm with 2.0 mm of temporal transposition improved elevation deficiency, but consecutive exotropia and hypotropia remained. Knapp procedure combined with left lateral rectus recession of 5.5 mm and left medial rectus resection of 4.5 mm, and right superior rectus recession of 9.5 mm were additionally performed. Pseudoptosis and chin elevation resolved but left hypotropia 10PD, and exotropia 6PD remained. Elevation restriction in primary position and abduction were improved but still persisted. This case indicated that MED may accompany congenital inferior rectus anomaly. If severe inferior rectus restriction is observed during the forced duction test, a structural anomaly of the inferior rectus causing motility defects of MED.

A Case of Congenital Monocular Elevation Deficiency Associated with Inferior Rectus Anomaly

PURPOSE: To report a congenital monocular elevation deficiency (MED) associated with inferior rectus anomaly. CASE SUMMARY: A 3-year-old, otherwise healthy boy presented with left hypotropia. He showed chin-up and left head turn with left pseudoptosis. On examination, there was a left hypertropia of 60 prism diopters (PD) and esotropia in primary position. Upgaze -4 limitation in abduction and -3 from primary position, poor Bell's phenomenon, and normal vertical saccadic velocity until midline were observed. On orbital CT, thin and nasally displaced left inferior rectus showing enlargement at its posterior segments near the orbital apex was observed. Forced duction test at surgery revealed a strong positive restriction and thin, taut, fibrotic inferior rectus was inserted and displaced nasally. CONCLUSIONS: Left inferior rectus recession of 5.5 mm with 2.0 mm of temporal transposition improved elevation deficiency, but consecutive exotropia and hypotropia remained. Knapp procedure combined with left lateral rectus recession of 5.5 mm and left medial rectus resection of 4.5 mm, and right superior rectus recession of 9.5 mm were additionally performed. Pseudoptosis and chin elevation resolved but left hypotropia 10PD, and exotropia 6PD remained. Elevation restriction in primary position and abduction were improved but still persisted. This case indicated that MED may accompany congenital inferior rectus anomaly. If severe inferior rectus restriction is observed during the forced duction test, a structural anomaly of the inferior rectus causing motility defects of MED.