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OBJECTIVE:To optimize the decoction technology of Zhuanggufang decoction powder. METHODS:Central com-posite design with 2 factors and 5 levels was conducted to design the test,taking water (fold) and decoction time as independent variables,the extraction amount of icariin and extraction yield overall desirability value of as dependent variables,regression equa-tion were fitted;response surface method was used to optimize the decoction technology of Zhuanggufang decoction powder,and was verified. It was compared with the traditional decoction piece effect. RESULTS:The optimized technology was decocted twice with 16-fold water,20 min each time;relative error of predicted and theoretical value by overall desirability value was 2.97%;af-ter decoction powder and piece decocted in the same conditions,the extraction amounts of icariin were 1.2343 μg/g and 1.1324μg/g,extraction yields were 23.73% and 17.84%,respectively. CONCLUSIONS:Central composite design-response surface meth-od optimizing decoction technology is simple and reliable,the optimized decoction technology is stable and feasible,and the decoc-tion capability of Zhuanggufang decoction powder is better than the traditional pieces.
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0.05);the bacteriological effection rates were 62.50% vs. 40.43%(P
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OBJECTIVE:To probe into the utilization of traditional Chinese medicine (TCM) injection in our hospital from 2005 to 2009.METHODS:The utilization of TCM injection used in our hospital from 2005 to 2009 was analyzed statistically in respects of consumption sum,DDDs and DDC.RESULTS:The mean annual incremental rate of the consumption sum of TCM injection in our hospital reached 24.89%.TCM injection for blood-activiating and stasis-dissolving dominated the first places in the lists of consumption sum and DDD for 5 years.TCM injection for anti-tumor took up the leading place in the list of DDC.More than 80% of TCM injection were medica1 insurance drug and new rural cooperative medicare drugs.CONCLUSION:The utilization of TCM injection in our hospital is reasonable and increase year by year.TCM injection with suitable price and extract efficacy take up a big proportion in the clinical application.It should be strengthened to adopt TCM injection reasonably.
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OBJECTIVE:To probe into the characteristics of adverse drug reactions (ADR) occurred in our hospital. METHODS: 340 ADR cases collected from Jan. 2004 to Dec. 2008 in our hospital were analyzed retrospectively. RESULTS: Of the total 340 ADR cases,80 (23.53%) were collected from pharmacy department;63.83% occurred in patients aged from 21 to 60 years,with females showing higher proportion than males;83.24% were induced intravenously,48.08% were induced by anti-infective drugs,of which,cephalosprins and quinolones took the lead. 38.05% of the ADR manifested as lesion of skin and its appendants. CONCLUSION: ADR monitoring should be strengthened in clinic;furthermore,the quality of ADR reporting should be improved and the use of drugs should be rationally in a standard way so as to lessen or avoid the occurrence of ADR.