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Journal of Clinical Otorhinolaryngology Head and Neck Surgery ; (24): 261-263, 2010.
Article in Chinese | WPRIM | ID: wpr-746619

ABSTRACT

OBJECTIVE@#To clarify the association between regulatory region of HLA-DPB1 (3'UTR) with Naso pharyngeal carcinoma in Guangdong Province Hans.@*METHOD@#The allelic types of HLA-DPB1-3'UTR were detected by sequence specific primer (SSP) in 104 patients with NPC and 105 control individuals from Guangdong Province Hans.@*RESULT@#The frequencies of allelic types B/B, haplotype B were higher in patients with NPC than those of the control individuals.@*CONCLUSION@#Positive association may exist between certain HLA-DPB1 alleles and NPC in Guangdong Province Hans.


Subject(s)
Humans , Alleles , Asian People , Genetics , Base Sequence , Case-Control Studies , Gene Frequency , HLA-DP Antigens , Genetics , HLA-DP beta-Chains , Haplotypes , Molecular Sequence Data , Nasopharyngeal Neoplasms , Genetics , Polymorphism, Single Nucleotide
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