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Objective To investigate the outcomes of patients with diabetic retinopathy (DR) in Shanghai communities and the influencing factors.Methods From October 2015 to April 2016,533 type 2 diabetic patients with DR were selected by target sampling and cluster random sampling method from six community health service centers in Shanghai.Patients were followed up for 1 year.The demographic information,physical examination,laboratory tests and eye fundus exam results were documented and the DR was graded.The factors associated with the regression of DR were analyzed.Results Total 478 patients,including 280 females (58.6％) and 198 males (41.4％),were followed up for 1 year.The mean age of patients was (64±7) years and the mean disease duration was (8.85±4.20) years.The original DR lesion was remitted in 35 patients with an improvement rate of 7.3％;while the original DR lesion was aggravated in 29 patients with a progression rate of 6.1％.Ordinal logistic regression analysis revealed that age (OR=0.197,95％CI:0.056-0.699),body mass index (BMI) (OR=0.383,95％CI:0.171-0.856),glycosylated hemoglobin (HbAlc) (OR=0.287,95％CI:0.102-0.803),triglycerides (TG) (OR=0.541,95％CI:0.295-0.991),urinary albumin to creatinine ratio (ACR)(OR=0.218,95％CI:0.066-0.720) were associated with DR in type 2 diabetic patients.Conclusion The regression of DR is closely related to age,BMI,glucose,serum lipids and renal function,so it is suggested that lowering BMI,controlling glucose and serum lipids and maintaining normal kidney function are necessary for preventing the progression and promoting the improvement of DR in diabetic patients.
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OBJECTIVE:To investigate the characteristics of adverse drug reactions(ADR)of our hospital so as to promote rational drug use in the clinic.METHODS:1162ADR cases collected during2002～2004in our hospital were analyzed retrospectively.RESULTS:The occurrence of ADR induced by combined use of drugs accounted for33.6%of the total(390cases),chiefly through IV.Altogether531kinds of drugs involved ADR,in which the anti-infective agents(110kinds)took the lead which amounted to51.3percent of the total,then came the antineoplastic agents,cardiovascular system medicines and Chinese drugs preparations.The first3drugs that involved highest frequency of ADR occurrences were levofloxacin,cefo?peazone/sulbactam and azithromycin.The main clinic manifestations of ADR were skin damage,then gastro-intestinal damage and etc.There were28serious ADR cases.CONCLUSION:The cultivation of professional ability and quality of professional staff should be strengthened and an omnibearing ADR monitoring work should be carried out so as to reduce and avoid the occurrence of ADR.
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OBJECTIVE: To probe into the status quo of cardiovascular drug-induced ADR and to provide reference for clinical utilization and ADR monitoring. METHODS: A total of 215 ADR cases of our hospital during 2003～2008 collected from electronic reporting system were classified, analyzed and evaluated. RESULTS: 84 kinds of drugs were involved, of which adrenergic agent occupied the dominant place (n=78), followed by calcium antagonists, anticoagulant, fibrinolytic agents and AT1R bloker. 18 cases induced by TCM involved 9 kind of Chinese patent drug. The first 3 drugs that involved in term of frequency of ADR were buflomedil, amlodipine and alprostadil. The main clinic manifestations of ADRs were lesion of skin and its appendants, psychological system and digestive system. CONCLUSION: More attention should be paid to safety of long-term prescription in such chronic disease and cardiovascular drug-induced ADR monitoring.
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OBJECTIVE:To understand the situation of adverse drug reactions occured and the harm to pa?tients.METHODS:298cases reported in our hospital were classified,analysed and evaluated.RESULTS:165kinds of drug caused adverse drug reactions,of which anti-infective agents occupied the first place,anticancer agents the second,cardiovas?cular and herbal agents induced ADRs very often too.The combined use of drugs accounted for28.5%in patients with ADRs.Most ADRs were induced by drugs given via intravenous route.The main types of ADRs were skin damage,gastro-intestinal damage,fever,etc.20cases had severe ADRs(6.7%).CONCLUSION:The adverse drug reactions difficult to observe and chronic ones should be paid more attention to.