ABSTRACT
Thyroglossal duct carcinoma is a malignant tumor which occurs in the thyroglossal duct cyst. The incidence of thyroglossal duct carcinoma has been reported as approximately 1%. Up to now, just about 250 cases of thyroglossal duct carcinoma have been reported in the literature,most of which are single case reports and small case series. In most cases, the diagnosis of the thyroglossal duct carcinoma is not made until the histologic examination after surgery operation. The preoperative examination such as CT or fine needle aspiration cytology can help the preoperative diagnosis. But the surgical treatment for the thyroglossal duct carcinoma is still controversial. Now we report a case of a thyroglossal duct carcinoma combined with systemic lupus erythematosus. The patient herself found an anterior neck mass in the median submental region one year ago. The preoperative CT examination suggested thyroglossal duct cyst with pouch canceration(papillary carcinoma). Then she underwent a Sistrunk procedure and level I neck dissection, and the histopathological diagnosis was thyroglossal duct carcinoma. The patient was treated with levothyroxine therapy at suppressive dose after the surgery. Now the patient is at regular follow-up with no relapse occur.
Subject(s)
Female , Humans , Biopsy, Fine-Needle , Carcinoma, Papillary , Diagnosis , Pathology , Lupus Erythematosus, Systemic , Diagnosis , Pathology , Neck Dissection , Skin , Thyroglossal Cyst , Diagnosis , Pathology , Thyroid Neoplasms , Diagnosis , PathologyABSTRACT
<p><b>OBJECTIVE</b>To compare the expression patterns of cytokeratin 7 (CK7) and CK20 in the Barrett's esophagus and gastric cardia intestinal metaplasia.</p><p><b>METHODS</b>Endoscopic biopsy specimens from 19 patients with long segment Barrett's esophagus, 36 with short segment Barrett's esophagus, and 20 with histological evidence of gastric cardia intestinal metaplasia were immunostained for CK7 and CK20. The immunohistochemical data were analyzed in relation with the clinicopathological data of the patients including age, hiatal hernia, and Helicobacter pylori status.</p><p><b>RESULTS</b>The Barrett's pattern of CK7/20 expressions was found in all the 19 patients with long segment Barrett's esophagus, in 31 of the 36 (82%) patients with short segment Barrett's esophagus, and in 2 of the 20 (10%) patients with gastric cardia intestinal metaplasia. Patients with short segment Barrett's esophagus who had a Barrett's CK7/20 pattern showed similar clinicopathological findings to those with long segment Barrett's esophagus, while in cases of short segment Barrett's esophagus where no Barrett's CK7/20 pattern was found, the clinicopathological features were similar to those of gastric cardia intestinal metaplasia cases.</p><p><b>CONCLUSION</b>A Barrett's CK7/20 expression pattern is an objective marker of Barrett's mucosa. CK7 and CK20 reactivity patterns in routine endoscopic biopsy samples can reliably identify the location of intestinal metaplasia in the esophagus and stomach.</p>
Subject(s)
Adult , Aged , Female , Humans , Male , Middle Aged , Barrett Esophagus , Diagnosis , Metabolism , Pathology , Biomarkers , Metabolism , Cardia , Metabolism , Pathology , Keratin-20 , Metabolism , Keratin-7 , Metabolism , Reagent Kits, DiagnosticABSTRACT
OBJECTIVE@#To observe the GluR2 expression in rat inferior colliculus (IC) in different developmental stages, and to investigate its developmental change and relationship with the synapse development.@*METHOD@#The expression of GluR2 and synaptophysin(SYP) in IC were detected by double immunofluorescence method.@*RESULT@#(1) All sorts of neurons in IC expressed GluR2 in every postnatal groups, and the GluR2 expression in P6w groups was higher than that in other groups. (2) The expression of GluR2 were different in different subnucleus of IC. (3) All sorts of neurons in IC expressed SYP in every postnatal groups, and the SYP expression in P6w groups was higher than others. (4) The expressions of GluR2 consistent with the expression of SYP in IC.@*CONCLUSION@#The developmental changes of GluR2 and SYP expression in the rat IC may be involved in the development and plasticity of auditory center.
Subject(s)
Animals , Rats , Hypothalamus , Cell Biology , Metabolism , Inferior Colliculi , Metabolism , Rats, Sprague-Dawley , Receptors, AMPA , Metabolism , Synapses , Metabolism , Synaptophysin , MetabolismABSTRACT
Objective:To observe the GluR2 expression in rat inferior colliculus (IC) in different developmental stages , and to investigate its developmental change and relationship with the synapse development.Method: The expression of GluR2 and synaptophysin(SYP) in IC were detected by double immunofluorescence method.Result:①All sorts of neurons in IC expressed GluR2 in every postnatal groups, and the GluR2 expression in P6w groups was higher than that in other groups .②The expression of GluR2 were different in different subnucleus of IC.③All sorts of neurons in IC expressed SYP in every postnatal groups, and the SYP expression in P6w groups was higher than others. ④The expressions of GluR2 consistented with the expression of SYP in IC.Conclusion:The developmental changes of GluR2 and SYP expression in the rat IC may be involved in the development and plasticity of auditory center.
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OBJECTIVE To investigate a case of nosocomial infection incident in a hospital,analyze the reasons and put forward preventive measures.METHODS Investigation was carried out on the related people and environment in the department where the incident occurred.Analysis was made on the reasons and processing.RESULTS The nosocomial infection incident was caused by Norovirus;fecal-oral transmission and contact transmission were 2 main pathways of Norovirus.There were 7 persons who had been contaminated by Norovirus,included 5 old inpatients,1 doctor and 1 nurse.CONCLUSIONS Many people should work to prevent and control the infections in hospital,such as doctors,nurses,inpatients,hospital works etc.Hand-washing and disinfection isolation should be enhanced among the hospital staffs in the normal works.
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OBJECTIVE To understand the situation of the nosocomial infection among the hospital inpatients in a grade-A hospital in Beijing.METHODS Surveillance on nosocomial infection was performed among the hospital inpatients from Jan 2005 to Dec 2007.RESULTS From Sept 2006 to Aug 2007,803 cases were infected,the incidence was 1.99%.The lower respiratory tract ranked the first place(38.97%)and the highest infected rate was in ICU(16.16%).The species were predominated by Gram-negatives.The main pathogenic microorganisms were Pseudomonas aeruginosa,Staphylococcus aureus,Escherichia coli,Acinetobacter baumannii,Klebsiella pneumoniae and Candida albicans,etc.From 2005 to 2007,the infections caused by P.aeruginosa increased gradually,and the infections caused by C.albicans reduced gradually.CONCLUSIONS Many people should work to prevent and control the infections in hospital,such as doctors,nurses,inpatients,management workers,etc.
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OBJECTIVE To seek the effective dynamic air disinfector for hospitals,and investigate the effects of JBL nano-meter dynamic air disinfector.METHODS Choosing four different hospitals,using JBL nano-meter dynamic air disinfector device to collect,compare and analyze the data under a human being movement environment or a vacant environment on the basis of the air sampling method taken from Hospital Disinfection Technology Standard(in 2002 edition) issued by the Ministry of Health.RESULTS When all four hospitals using JBL nano-meter dynamic air disinfectors,the average air bacterium-killing rate in a human being movement environment reached 80.35%,which was obviously better than other similar devices.CONCLUSIONS JBL nano-meter dynamic air disinfector not only has very good function of removing the unusual odors,but has excellent active air disinfection effect.Meanwhile,the device can be installed conveniently.It is regarded as one of the best hospital air disinfection devices.
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OBJECTIVE To investigate the current status of nosocomial infection management in grass roots cosmetologic medical institutions,and to develop the countermeasures for improving the management quality.METHODS An observatory study was conducted in 72 grass roots cosmetologic medical institutions,using the evaluation criteria based on the requirements of related regulations.RESULTS Problems were found in different extent in all of the grass roots cosmetologic medical institutions.The qualification rate was only 38.9%.The existing risk factors might occur nosocomial infections.CONCLUSIONS To bring the special attention to management of nosocomial infections,strengthen training of medical staffs and improve supervision level of health administration department are the key issues of management of nosocomial infection in grass roots cosmetologic medical institutions.