ABSTRACT
Plasma endothelin-1 (ET-1),von Willebrand factor ( vWF) and fibrin D-dimer (D-D) were determined in 14 children with schnlein-henoch purpuric nephritis (SHN),17 children with schnlein-hen och purp ura (SHP, no abnormal finding in the examination of the urinary system) and 12 children as normal controls, respectively. The results showed that plasma ET-1( 88.48±22.96ng/L),vWF(1.59±0.38U/ml) and D-D(1.45±0.39)mg/L in the SH N group were all significantly higher than those in both of the control group (4 3.73±17.89)ng/L, (0.99±0.3)U/ml and (0.28±0.23)mg/L and the SHP group (57. 54±20.92)ng/L, (1.5±0.31)U/ml and (0.64±0.34)mg/L although no significa ntly difference in the levels of vWF was observed between SHN and SHP groups. It was noticed that the levels of three parameters decreased significantly in the SHN g roup after treatment (all P＜0.01). There was a positive correlati on between the levels of plasma ET-1 and D-D with serum creatinine (all P＜0.01). It is suggested that excessive ET-1 induced by endothelial dam age of renal vessels, intravascular coagulation and secondary fibrinolysis are p robably involved in the process of renal damage.
ABSTRACT
The peripheral blood T lymphocyte subsets and ConA-induced suppressor cell activity (ConA-SCA) were determined in 37 patients with primary nephritic syndrome(PNS). The results showed that the patients in initial onset had the abnormal number and function of T lymphocytes, which returned to a normal level with treatment with steroid and improvement of patients'condition. The indings suggest that the immunoregulatory imbalance of this disease may be a primary change and play an important role in pathogenesis of PNS.