Association of Polymorphisms in DAZL Gene with Male Infertility.

Objectives: To investigate the association between A260G (Thr12Ala) and A386G (Thr54Ala) single nucleotide polymorphisms (SNPs) in deleted in azoospermia-like gene (DAZL) and infertility in Jordanian males. Methods: Infertile 170 patients with azoospermia or oligozoospermia and 176 fertile subjects were recruited in the study. DAZL SNPs were genotyped using polymerase chain reaction-restriction fragment length polymorphisms (PCR-RFLP). Results: The data showed that the A260G SNP is common in the Jordanian population with frequency of 10.3% for 260G mutant allele. However, the A386G SNP is absent in the studied population. No significant association was found between the examined SNPs in DAZL gene and men infertility. Conclusion: The A260G and A386G polymorphisms of DAZL seem to play no role in men infertility in Jordanian population.

Transverse lie in Northern Jordan: risk factors, obstetric and perinatal outcome

This study describes the incidence, risk factors, obstetric and perinatal outcome of transverse lie in singleton pregnancies at term at the Princess Badeea Teaching Hospital in Northern Jordan. A retrospective study was undertaken for woman who delivered over a 5-year period from January 1997 to January 2002. There were 164 cases of term transverse lie out of 45,763 deliveries during the study period. The incidence of transverse lie at term was 0.36%. This occurred more commonly in grandmultiparous[79.3%] in comparison to low parous [14.6%] and primigravid [6.1%] woman. The most common risk factors associated with transverse lie were placenta praevia [7.3%], polyhydramnios [4.9%], uterine anomalies [3.7%] and contracted pelvis [3%]. The antenatal and intrapartum complications associated with this condition were premature rupture of membranes [10.4%], antepartum haemorrhage [6.1%] cord prolapse [3%] and uterine rupture [0.6%]. The majority of women were delivered by emergency caesarean section [73.8%] and 18.9% of women were delivered by elective caesarean section. External cephalic version and successful vaginal delivery were achieved in 7.3% of women. The perinatal mortality was 42.7 per 1000 births. There were 7 cases of perinatal deaths; 3 stillbirths and 4 early neonatal deaths. Better antenatal care and the use of ultrasonography will lead to early diagnosis of transverse lie. Elective admission and delivery, whether by caesarean section of vaginally after external cephalic version of such cases will minimize if not completely eliminate, the major, hazards associated with transverse lie in labour