ABSTRACT
Objective To evaluate the efficacy and safety of cefepime in the treatment of serious community acquired lower respiratory infection. Methods Eighty-six patients of serious community acquired lower respiratory infection were randomized into the experimental group (n=44) receiving cefepime (2 g, intravenous infusion, twice a day) for 7-14 d and the control group (n=42) receiving cefotaxime (3 g, intravenous infusion, three times a day) for 7-14 d. Results There were no statistical differences of age, severity of the disease, original diseases, or distribution of pathogens between the two groups. In the experimental group, cefepime had a good therapeutic efficacy against not only the gram-negative bacteria infection and the gram-positive bacteria infection, but also other cephalosporin-resistant bacteria infection. Its cure rate was 86.4%, and effective rate 93.2%. In the control group, cefotaxime had a less therapeutic efficacy against the infection caused by some resistant strains of the gram-negative bacteria and the gram-positive bacteria. Its cure rate was 64.3%, and effective rate 76.2%. Conclusion The antibacterial activity of cefepime is stronger than that of cefotaxime. So cefepime is an effective and safe antibiotic, and suggested to use in the empirical treatment for serious community acquired lower respiratory infection.
ABSTRACT
Objective In a RCT study, the safety and efficacy of sabot (a slow-release salbuteral) and volmax (controlled-release salbuterol) were compared in bronchial asthma. Methods 40 patients with moderate to severe asthma were randomly divided into two groups and treated by sabot or volmax for 2 weeks. The FEV1%, peak expiratory flow (PEF), symptom score and use of rescue ventolin were measured to evaluate the effect of treatment. Results After treatment FEV1%, PEF and symptom score improved and the need for inhaling short-acting beta 2-agonis in both groups reduced significantly. There was no difference of these improvement between two groups. Conclusion The safety and efficacy of sabot for treatment of asthma was similar to volmax.