ABSTRACT
The purpose of this study is to find out whether there are broad cross-reactivity between antibacterial and nonantibacterial sulfonamide agents, the method of the study contained two parts, one is literature research mainlyfrom PubMed database by using the MeSH terms (“Drug name” + allergy); (“Drug name” + hypersensitivity);(“Drug name” + cross-allergenicity) and (“Drug name + cross-reactivity), the search drugs included somecommonly seen medication such as carbonic anhydrase inhibitor, COX-2 inhibitor, loop diuretic, sulfonylurea,thiazide and certain antiviral drugs; the other parts of this thesis is to conduct a statistical review, we screen outpatients who have a previous allergic history of antimicrobial sulfonamides from hospital medical record systemduring Jan 1st, 2015 to Dec 31th, 2016, we did a descriptive statistics of general patients medical information,analyze the suspect cases which patients present potential allergic reaction after using non-antimicrobialsulfonamides agents. Result of literature research reveal there are no convincing evidences and research toconfirm there are bored allergenicity between non-antimicrobial sulfonamides and antimicrobial sulfonamide inthe aspects of chemical structure, immunological study, and large scale population study as well; Result ofhospital patient’s statistics found out there are only 3 suspected cases that the patients were having adverseeffect during their pharmacotherapy from 506 cases. However, we did not found any strong correlation of broadallergenicity between non-antimicrobial sulfonamides and antimicrobial sulfonamides from these suspectedcases. Conclusion: There is minimal evidence of cross-reactivity between the antimicrobial sulfonamides and thenon-antimicrobial sulfonamides. However, the non-antimicrobial sulfonamides are rarely implicated inhypersensitivity reactions as well, so it is impossible to say with certainty that cross-reactivity does not occur.
ABSTRACT
Objective@#To investigate the effects of probiotics on liver function, glucose and lipids metabolism, fecal flora in children with nonalcoholic fatty liver disease (NAFLD), and to further provide a reference for analyzing the feasibility and effectiveness of the treatment of NAFLD.@*Methods@#A total of 120 children with NAFLD during June 2017 to December 2018 in The Fenghua People’s Hospital of Ningbo were randomly divided into observation group and control group, 60 cases in each group. The control group received diet and exercise therapy, while the observation group received orally probiotics based on the control group, and the intervention lasted for 3 months. The indexes of liver function, glucose and lipids metabolism, the effective rate and imbalance of fecal flora in two groups were compared before and after intervention.@*Results@#Before treatment, there were no significant differences in alanine aminotransferase (ALT), aspartate aminotransferase (AST), glutamine transferase (GGT), total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), insulin resistance index (HOMA-IR) and imbalance of fecal flora in two groups were compared before and after intervention (P>0.05). For the comparisons after treatment in two groups, including the ALT (30.49±11.03 vs 24.76±9.54)U/L, AST (37.66±12.91 vs 32.05±12.38)U/L, GGT (20.81±8.32 vs 16.07±6.69)U/L, TC (3.90±0.93 vs 3.41±0.87)mmol/L, TG (1.50±0.42 vs 1.14±0.40)mmol/L, HOMA-IR (1.46±0.53 vs 1.22±0.45), these parameters in observation group was higher than those in control group, and the differences were statistically significant(t=3.04，2.43，3.44，2.98，4.81，2.67，P<0.05); After treatment, the imbalance of fecal flora in the observation group was better than that in the control group, and the difference was statistically significant (Hc=8.34, P=0.02).@*Conclusion@#Probiotics are beneficial for liver function, glucose and lipid metabolism, fecal flora for NAFLD patients in children, so as to enhance the therapeutic effect of NAFLD.
ABSTRACT
Objective @#To observe the effects of arecoline on the related protein expressions in the apoptosis of cultured human periodontal ligament fibroblasts (hPDLFs), such as p-JNK, p-p53, and Bcl-2.@*Methods @#hPDLFs were isolated from human periodontal ligament tissues and expanded in vitro. hPDLFs were treated with different concentrations of arecoline (0, 20, 40 and 80 μg/mL) for 12 h. The proliferative activities were evaluated by MTT. The expressions of p-JNK, p-p53, and Bcl-2 were determined by Western blot. @*Results@#Arecoline inhibited cell proliferation and induced apoptosis protein. The protein level of Bcl-2 was decreased, while p-JNK and p-p53 were increased (P < 0.05). The protein expressions were in a concentration-dependent manner with arecoline. @*Conclusion @#It demonstrates arecoline might contribute to the apoptosis of hPDLFs, and could destroy periodontal tissues.