ABSTRACT
<p><b>OBJECTIVE</b>To study the protection of puerarin on the cerebral injury in the rats with acute local ischemia.</p><p><b>METHOD</b>Rat was evaluated model of acute local cerebral ischemia was made by ligating middle cerebral artery. The cerebral damage toxylin and eosin((HE).</p><p><b>RESULT</b>The number of died neurons were significantly less in puerarin-treated rats than in the rats with cerebral ischemia (P < 0. 05). Similarly, the cerebral edema were significantly attenuated in the puerarin-treated rats as compared with cerebrally ischemic rats.</p><p><b>CONCLUSION</b>Puerarin can prevent the neuron from damage induced by acute cerebral ischemia.</p>
Subject(s)
Animals , Female , Male , Rats , Brain Ischemia , Pathology , Cell Death , Cerebral Cortex , Pathology , Infarction, Middle Cerebral Artery , Pathology , Isoflavones , Pharmacology , Neurons , Neuroprotective Agents , Pharmacology , Rats, Wistar , Vasodilator Agents , PharmacologyABSTRACT
<p><b>OBJECTIVE</b>To study the effect of puerarin on the expression of Hsp (heat shock protein) 70 in the rats with cerebral injury induced by acute local ischemia.</p><p><b>METHOD</b>Rat model of acute local cerebral ischemia was made by ligating middle cerebral artery. The Hsp70 expression in brain tissue was detected by SP method of immunohistochemistry.</p><p><b>RESULT</b>The expression of Hsp70 was significantly higher in puerarintreated rats than those in the rats with cerebral ischemia.</p><p><b>CONCLUSION</b>Puerarin can enhance the level of Hsp70 expression in the rats with cerebral injury induced by acute local ischemia.</p>