ABSTRACT
<p><b>AIM</b>To investigate the extent of systemic absorption and uptake of meptazinol (MEP) hydrochloride in cerebrospinal fluid (CSF) after intranasal administration on rats and compare with oral administration.</p><p><b>METHODS</b>CSF samples were collected by a serial sampling method. The concentration of MEP in the biological samples was measured by HPLC with fluorescence detector.</p><p><b>RESULTS</b>Rapid and significant levels of MEP in plasma and CSF can be achieved after nasal administration whereas the oral administration resulted in considerably lower drug concentrations. AUC in plasma and CSF from the nasal route are 7.375 and 15.6 folds compared with those of the oral route, respectively.</p><p><b>CONCLUSION</b>Intranasal MEP is able to show quick absorption and improve the bioavailability, which could be a promising alternative to oral administration.</p>
Subject(s)
Animals , Male , Rats , Administration, Intranasal , Administration, Oral , Analgesics, Opioid , Blood , Cerebrospinal Fluid , Pharmacokinetics , Area Under Curve , Biological Availability , Chromatography, High Pressure Liquid , Methods , Meptazinol , Blood , Cerebrospinal Fluid , Pharmacokinetics , Rats, Sprague-DawleyABSTRACT
<p><b>AIM</b>To investigate the effect of nimodipine (NM) on cerebral blood flow (CBF) in dogs following intranasal administration.</p><p><b>METHODS</b>NM solution was administered intranasally, intravenously (i.v.), and orally to dogs and the change of CBF was determined by using electromagnetic blood flowmeter. MFLab experimental program was applied to monitor the experimental process and analyze data.</p><p><b>RESULTS</b>CBF markedly increased after iv and intranasal application, while large variance was observed after oral dosing. CBF in dogs after three administrations increased by 26.4%, 28.0% and 8.5%, respectively, compared with that of baseline. Following intranasal administration, the onset of action was slightly slower than that after iv injection [(5 +/- 4) min vs (2.2 +/- 1.2) min], however the duration of improvement was the longest [ (25 +/- 17) min].</p><p><b>CONCLUSION</b>Intranasal delivery for NM can be a promising alternative to parenteral or oral administration.</p>