ABSTRACT
OBJECTIVE@#Obstructive sleep apnea hypopnea syndrome (OSAHS) and non-alcoholic fatty liver disease (NAFLD) are both strongly associated with obesity. Whether OSAHS is an independent risk factor for liver injury or not is uncertain. To assess the hypothesis that OSAHS is associated with liver injury independent of obesity.@*METHOD@#One hundred and thirty children with OSAHS and 77 children with primary snoring(PS) were enrolled. Polysomnography was performed. Body mass index (BMI), liver function tests, serum lipids, fasting plasma glucose (FPG), and insulin (INS) were measured.@*RESULT@#Seventeen children of OSAHS had elevated serum aminotransferase levels,while only 2 children of non-OSAHS had elevated serum aminotransferase in healthy control group (chi2 = 5.18, P < 0.05; OR = 5.64 CI 1.27-24.97). Fifteen children of obese had elevated serum aminotransferase levels, while only 4 children had elevated serum aminotransferase in non-obese group (chi2 = 4.58, P < 0.05; (OR = 1.97 CI 1.06-3.67). Seventy cases of obese children, 15 cases of elevated aminotransferase levels (21.4%), namely fatty liver patients, of these children, 14 had OSAHS (93.3%). In contrast, OSAHS was present in only 67.3% of obese children without elevated aminotransferase.@*CONCLUSION@#OSAHS may be a risk factor for liver injury independent of obesity; Increased liver enzyme levels are frequently found in obese snoring children, particularly among those with OSAHS.
Subject(s)
Adolescent , Child , Female , Humans , Male , Blood Glucose , Body Mass Index , Case-Control Studies , Fatty Liver , Blood , Insulin , Blood , Obesity , Blood , Risk Factors , Sleep Apnea, Obstructive , Blood , Snoring , Blood , Transaminases , BloodABSTRACT
Objective To observe the effects of embedding implantation of collagen and Tetramethylpyrazine in acupoints and electro-acupuncture on the expression of HSP70 in hippocampus of rat with focal cerebral ischemia reperfusion. Methods SD rats were randomly divided into normal group, sham operation group, model group, electro-acupuncture group, embedding medicine in acupoints group. Model of local ischemia was made by middle cerebral artery occlusion, preparation of implantation collagen and electro acupuncture and Tetramethylpyrazine was embedded in the acupoints of Dazhui and Neiguan two-sided. The expression of HSP-70 protein in hippocampus of different time point (24, 72, 120 h) was assayed by immunohistochemistry. Results There were only few positive cells of HSP-70 in normal group and sham operation group. The expression of HSP-70 in each therapy group were all heightened, and achieved the peak 24 h later and then declined in brain tissue after focal cerebral ischemiareperfusion, the differences were relatively prominent compared with the same phase model group (P
ABSTRACT
Isoelectric focusina Electrophoresis(lFE)was use to detenmine the isoelectric point of main protein composition in Chinese Traditional Medicine (TCM ) either of animal origin Such as (EuPotyPhage sinenses)orfrom fruit or seed of plants (such as the seed of CeIosia urgeatea). Results showed that their IFE bands werealways quite distinct,which can be used to assess their quality and to distinguish them from confusable varieties.
ABSTRACT
Ultraviolet spectrophotomety was used to determine Tween-80 critical micell concentration (CMC) in different Chinese herbal medicine injections. Studies on the concentration of iodine solution and wavelength suitable for the determinntion were carried out. This method is quick and accurate and can be used for the quality control of such preparation.