Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 1 de 1
Filter
1.
Article in Chinese | WPRIM | ID: wpr-298418

ABSTRACT

<p><b>OBJECTIVE</b>To optimize the formulation and preparation process of sinomenine liposomes.</p><p><b>METHOD</b>Method of aether injection and mixture uniform design were adopted to determine the formulation of sinomenine liposomes is the proportion of phospholipids, cholesterol and Vitamin E with the index of entrapment efficiency. And the single-factor test was used to study the preparation process of the liposomes, including the volume of buffer solution, the preparation temperature and the ultrasonic time.</p><p><b>RESULT</b>The optimized formulation was that the ratio of sinomenine : phospholipids : cholesterol : vitamin E mass ratio was 8.92 : 60.35 : 28.81 : 1.91. The volume of buffer solution was 50 mL x g(-1) membrane, the preparation temperature was 50 degrees C, and the ultrasonic time was 20 min.</p><p><b>CONCLUSION</b>Satisfactory shape and entrapment efficiency of the liposomes can be obtained by the optimized formulation and preparation process.</p>


Subject(s)
Chemistry, Pharmaceutical , Cholesterol , Dosage Forms , Drug Carriers , Drug Compounding , Economics , Methods , Drug Delivery Systems , Drug Stability , Liposomes , Morphinans , Pharmacokinetics , Particle Size , Phospholipids , Technology, Pharmaceutical
SELECTION OF CITATIONS
SEARCH DETAIL