ABSTRACT
AIM To investigate the effects of t ot al flavones metasequosia (TFM) on ischemia reperfusion injury in guinea pig work ing heart. METHODS Ischemia reperfusion injury model was used to evaluate the effects of TFM. Myocardial func tion, the content of CK、LDH and the activity of MDA were measured. RESU LT TFM improved the cardiac function, decreased the release of LDH and CK and inhibited the increase of MDA content. CONCLUSION TFM had a protective effect on ischemia reperfusion injury of myocardium which could be re lated to its inhibitory effect on lipid peroxidation.
ABSTRACT
AIM To study the protective effects of total flavones metasequosia(TFM) on experimental acute myocardial infarction (AMI) in anaesthetized dogs. METHODS The parameters of coronary circulation and myocardial oxygen consumption, the degree and range of myocardial ischemia, myocardial infarct size, the activity of serum CK,LDH and the content of FFA were determined by using the AMI model of ligature of LAD in the anaesthetized open-chest dogs. RESULTS In dogs treated with TFM(in a dosage of 25, 100 mg?kg -1 , id), the myocardial oxygen consumption, degree and range of myocardial ischemia, myocardial infarct size, the activity of serum CK,LDH and the content of FFA were decreased. At the same time, myocardial blood flow was increased and coronary vascular resistance decreased significantly. CONCLUSION TFM possesses a protective effect on myocardial ischemia by modifying dysfunction of FFA, decreasing myocardial oxygen consumption and increasing myocardial blood supply.-