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ObjectiveTo explore the relationship among loneliness， Internet addiction and online deviant behavior of students in police colleges， and to discuss the related mechanism. MethodsIn March 2020， 766 students from a police college in Sichuan were selected by cluster sampling method， and assessed using University of California at Los Angeles-Loneliness Scale （UCLA-LS）， Diagnostic Scale for Internet Addiction Disorder （DSFIAD） and College Students' Online Deviant Behavior Questionnaire， then SPSS 20.0 software was used for statistical， and Mplus 8.0 software was used to test the mediating and moderating effects. Results①The Online Deviant Behavior Questionnaire score of male students in police college was higher than that of female students （t=7.560， P<0.01）. ②UCLA-LS score was positively correlated with DSFIAD score （r=0.406， P<0.01）， and Online Deviant Behavior Questionnaire score was positively correlated with UCLA-LS and DSFIAD scores （r=0.279， 0.592， P<0.01）. ③Loneliness could positively predict online deviant behavior （β=0.279， t=9.041， P<0.01）. ④Internet addiction played a full mediating role between loneliness and online deviant behavior， with a mediating effect size of 0.233 （95% CI： 0.190~0.279， P<0.01）， accounting for 83.51% of the total effect. ⑤Gender played a regulatory role in the second half （Internet addiction → online deviant behavior） of the intermediary path of "loneliness → Internet addiction → online deviant behavior" （β=-0.192， t=-4.461， P<0.01）. ConclusionThe loneliness of police college students cause a direct impact on the online deviant behavior， and also pose an indirect impact on online deviant behavior through Internet addiction. Furthermore， loneliness has a moderated mediation effect on online deviant behavior， and is only significant in the male students.
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We pretreated sawdust (Castanopsis fissa Rehd.et Wils) by solid state fermentation (SSF) with Phanerochaete chrysosporium, and then compressed it into pellets with the moisture content of 15% and the pressure of 98 MPa, to solve the problem of low density, low Meyer hardness, high water uptake, and short storage period of pellet in the woody pellet industry. We studied the effects of fermentation time on pelletization and pellets's characteristics (including energy consumption, density, Meyer hardness, and hydrophobicity). SSF affected the heating values of pellet. Compared with fresh sawdust, SSF consumed more energy at the maximal value by 6.98% but saved extrusion energy by 32.19% at the maximum. Meanwhile, SSF could improve the density, Meyer hardness and hydrophobicity of pellet. Pellet made of sawdust pretreated by SSF for 48 d had best quality, beneficial for long-term transportation and storage of pellets.
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Biofuels , Fermentation , Hydrophobic and Hydrophilic Interactions , Phanerochaete , Water , WoodABSTRACT
Objective: To study the efficiency of silencing small ubiquitin-like modifier-1(SUMO-1) induced by siRNA in hepatocellular carcinoma cell line SMMC-7721 and the growth inhibition of SMMC-7721 thereof. Methods: The SUMO-1 siRNA was transfected into SMMC-7721 by means of lipofectamine~(TM) 2000. The silencing efficiency of SUMO-1 was examined by RT-PCR and western blot. The cell growth and cell cycle were examined by MTT and flow cytometry(FCM). The cell apoptosis was detected by DeadEnd~(TM) Colorimetric TUNEL System. Results: The siRNA could significantly silence the expression of SUMO-1 in SMMC-7721.The maximal silencing rate was utmost 73.43% at 48 hours after being transfected SUMO-1 siRNA. MTT assay revealed that the cell line grew more slowly. FCM result showed that the number of G_2 stage cells was increased significantly. But apoptosis cells were not found by TUNNEL assay. Conclusion: SiRNA is a good manner to silence the expression of SUMO-1 in SMMC-7721 in vitro. Owing to the growth inhibition induced by SUMO-1 siRNA, SUMO-1 plays an important role in development of SMMC-7721.
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<p><b>BACKGROUND</b>To evaluate the response, adverse effects and survival of MVP regimen and TVP regimen.</p><p><b>METHODS</b>Sixty six patients with advanced non-small cell lung cancer were randomized into two groups:MVP arm (32 patients, mitomycin C 6-8 mg/m² d1, vindesine 2-3 mg/m² d1 and d8, cisplatin 70-80 mg/m² d1) and TVP arm (34 patients, pirarubicin 40-50 mg/m² d1, vindesine and cisplatin were the same as arm MVP). Characteristics of the patients were similar in two arms. All patients received two to four cycles of chemotherapy.</p><p><b>RESULTS</b>The overall responses were 34% (11/32) in the MVP arm and 56% (19/34) in the TVP arm. There were 1 complete response, 10 partial responses in the MVP arm and 1 complete response, 18 partial responses in the TVP arm. TVP regimen appeared to have a higher objective response, but no statistically significant difference in the response was observed between two regimens (Chi-square=2.269, P=0.132). Main side effects were hematological toxicities. Grade III+IV hematological toxicities were significantly higher in the patients of arm TVP than arm MVP, especially neutropenia (79% vs 44%, Chi-square=7.458, P=0.006). Median survival time was 12 months vs 8 months, and 1-, 2-, 3-year survival rates were 53% vs 24% (Chi-square=4.943, P=0.026), 17% vs 6%, 6% vs 0, for arm TVP and arm MVP, respectively..</p><p><b>CONCLUSIONS</b>MVP regimen has a lower response rate and longer survival time but less hematological toxicities than TVP regimen. The results suggest MVP regimen is a safe and active regimen for advanced non-small cell lung cancer.</p>
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Obesity is a rapidly growing international health problem. The association of fat mass and obesity associated(FTO) gene and obesity is becoming the hot topic in the gene research. FTO is a member of the nonheme dioxygenase [Fe(Ⅱ) and 2-oxoglutarate-dependent dioxygenases]superfamily. FTO levels in the brain,especially in the hypothalamus,participate in the central control of food intake. The mutation of FTO gene accentuates body mass index,hip circumference and total weight,leading to obesity.