ABSTRACT
<p><b>OBJECTIVE</b>Try to use free jejunum flaps reconstruction and laryngeal preservation for squamous cell carcinoma (SCC) in the pharyngoesophageal junction.</p><p><b>METHODS</b>Thirteen patients who underwent resections of SCC in the pharyngoesophageal junction with free jejunal interposition from August 2007 to December 2012 were reviewed. Of them, 8 had T3 lesions, 4 had T4 lesions, and one had radiation failure with rT2 lesion. Ten patients were treated with postoperative radiotherapy with a average dosage of 56 Gy.</p><p><b>RESULTS</b>The 3 year over all survival rate was 47.9% and disease-specific survival rate was 34.2%. The surgical complications occurred in 9 patients (9/13), including one death and one flap failure. Five patients (5/13) had permanent tracheal canulation, 10 patients (10/13) resumed oral feeding and all patients achieved reasonable speech.</p><p><b>CONCLUSION</b>Free jejunum interposition can be used to reconstruct surgical defect of SCC in the pharyngoesophageal junction, thus preserving the larynx and ensuring a better quality of life for the patients.</p>
Subject(s)
Humans , Anastomosis, Surgical , Carcinoma, Squamous Cell , General Surgery , Esophagus , Jejunum , General Surgery , Larynx , Larynx, Artificial , Neck , Postoperative Complications , Quality of Life , Plastic Surgery Procedures , Methods , Surgical Flaps , Survival RateABSTRACT
OBJECTIVE@#To explore the expression and significance of survivin and proliferating cell nuclear antigen (PCNA) on the occurrence, proliferation, recurrence and carcinogenesis of the sinonasal inverted papilloma (SNIP).@*METHOD@#Immunohistochemical method was used to detect the expression of survivin and PCNA in 10 cases of nasal cavity mucosal (NM), 45 cases of SNIP and 9 cases of canceration SNIP.@*RESULT@#The positive expression of survivin and PCNA increased gradually in NM,SNIP and canceration PCNA group, and there were significant difference between the three groups. But there was no correlation between survivin and PCNA in the tissue of SNIP (r = 0.135, P > 0.05).@*CONCLUSION@#Survivin and PCNA are involved in the growth and carcinogenesis of SNIP.