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Osteoporotic thoracolumbar fracture in the elderly will seriously reduce their quality of life and life expectancy. For osteoporotic thoracolumbar fracture in the elderly, spinal reconstruction is necessary, which should comprehensively consider factors such as the physical condition, fracture type, clinical characteristics and osteoporosis degree. While there lacks relevant clinical norms or guidelines on selection of spinal reconstruction strategies. In order to standardize the concept of spinal reconstruction for osteoporotic thoracolumbar fracture in the elderly, based on the principles of scientificity, practicality and progressiveness, the authors formulated the Clinical guideline for spinal reconstruction of osteoporotic thoracolumbar fracture in elderly patients ( version 2022), in which suggestions based on evidence of evidence-based medicine were put forward upon 10 important issues related to the fracture classification, non-operative treatment strategies and surgical treatment strategies in spinal reconstruction after osteoporosis thoracolumbar fracture in the elderly, hoping to provide a reference for clinical treatment.
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Objective To observe the effects of Angong Niuhuang Bolus(ANB) on vital organ injury and mortality in rats with sepsis.Methods SD rats were randomized into normal control group,model group,and low-,middle-and high-dose ANB groups(in the dose of 1.0,2.0 and 3.0 g?kg-1?d-1 respectively).Except that the normal control group,the rats in other groups received cecal ligation and puncture(CLP) method to induce sepsis through abdominal infection.ANB groups were given gastric gavage of ANB 0.5 hours before CLP and 6 hours after CLP.After CLP for 24 hours,the mortality was observed,serum levels of alanine aminotransferase(ALT),total bilirubin(TB) and creatinine were detected,and pulmonary myeloperoxidase(MPO) activity in all of the rats was examined.Results Serum ALT and TB levels,MAO activity and 24-hour mortality were increased in the model group(P
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[Objective] To observe the effect of Hewei Jiangni Decoction (HJD) for the treatment of stress ulcer and to explore its possible mechanism. [Methods] Sixty SD rats were randomized into 6 groups: normal, model, ranitidine (0.05 g?kg-1?d-1), and HJD groups (1.25, 2,50 and5.00g?kg-1?d-1 respectively). Except the normal group, the rats in other groups were treated with water immersion method to induce stress ulcer. Then the drugs according to the experimental design were administered to ranitidine and HJD groups for 5 days successively , and the model and normal groups were given saline. Gastric mucosal blood flow was detected by laser Doppler flowmeter, and inducible nitric oxide synthetase (iNOS) mRNA expression in gastric mucosa was examined by reverse transcriptase polymerase chain reaction (RT-PCR) . [Results] HJD decreased ulcer index, increased gastric mucosal blood flow (GMBF), and reduced iNOS mRNA expression in the gastric mucosa, the difference being significant ( P
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Objective To investigate the effect of Angong Niuhuang Bolus(ANB) on mRNA expression of high mobility group box-1(HMGB1) protein and myeloperoxidase activity in the lung of rats with sepsis induced by cecal ligation and puncture(CLP) method.Methods Seventy-five male SD rats were randomly divided into normal control group,model group,AG490(a Janusk kinase inhibitor) treatment group(subcutaneous injection of AG490 8mg/kg 0.5 h before CLP),rapamycin(RPM,a signal transduction and transcription activator inhibitor) treatment group(subcutaneous injection of RPM 0.4 mg/kg 0.5 h before CLP),and low-,middle-and high-dose ANB groups(gastric gavage of ANB in the dose of 1.0,2.0 and 3.0 g?kg-1?d-1 respectively).The animals were sacrificed 24h after CLP,and then lung tissue samples were collected to determine the expression of HMGB1 mRNA by the method of reverse transcription polymerase chain reaction(RT-PCR).Meanwhile,the activity of pulmonary myeloperoxidase(MPO) was also measured.Results Compared with the normal control group,the mRNA expression of HMGB1 was significantly enhanced(P
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Objective To investigate the serum high-mobility group box protein 1(HMGB1)level in sepsis patients with different syndrome patterns,and to explore the correlation of HMGB1 level with defense-Qi-nutrient-blood syndrome differentiation and Acute Physiological and Chronic Health Evaluation Ⅱ(APACHEⅡ)score.Methods Twenty-four sepsis patients were differentiated as Qi system syndrome(QS group,N=11)and nutrient-blood system syndrome(NB group,N=13).Eight healthy volunteers served as the normal control.APACHEⅡ score was evaluated,serum HMGB1 level was detected by Western blot method,and the correlation of HMGB1 level with defense-Qi-nutrient-blood syndrome differentiation and APACHEⅡ score was analyzed.Results APACHEⅡ score was higher in NB group than that in QS group,the difference being significant(P
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[Objective] To observe the effect of Hewei Jiangni Decoction (HJD) in preventing and treating stress ulcer in rats and to explore its therapeutic mechanism. [Methods] Sixty SD rats were randomized into groups A (model), B (ranitidine 0.05 g/kg), C (HJD 1.25 g/kg), D (HJD 2.5 g/kg) and E (HJD 5.0 g/kg). Rat models of stress ulcer were induced by water-immersion method. Model group was given normal saline and the rats in other groups were medicated by gavage for 5 days. After treatment, effects of HJD on the incidence of stress ulcer, volume and pH value of gastric juice, prostaglandin E2 (PGE2) and nitric oxide (NO) contents in gastric mucosa were detected. [Results] HJD decreased ulcer index, gastric secretion and NO content and increased the content of PGE2 ( P