ABSTRACT
Microglia plays multiple roles in the pathophysiology of schizophrenia .Activated microglia can induce a cascade of immune responses leading to neuroimmunological abnormalities , including the release of proinflammatory cytokines , the metabolic ab-normalities of the kynurenic acid pathway , and the oxidative stress response .On the other hand , it can lead to the neurodevelopmental abnormalities through the abnormal pruning of synapses and reducing the lack of neurotrophic support , eventually having psychotic symptoms.This article reviews the recent advances in the pathogenesis of microglia being involved in schizophrenia .
ABSTRACT
Microglia plays multiple roles in the pathophysiology of schizophrenia .Activated microglia can induce a cascade of immune responses leading to neuroimmunological abnormalities , including the release of proinflammatory cytokines , the metabolic ab-normalities of the kynurenic acid pathway , and the oxidative stress response .On the other hand , it can lead to the neurodevelopmental abnormalities through the abnormal pruning of synapses and reducing the lack of neurotrophic support , eventually having psychotic symptoms.This article reviews the recent advances in the pathogenesis of microglia being involved in schizophrenia .