ABSTRACT
Background: In obesity insulin hypersecretion is a key feature indicating the abnormal pancreatic beta cell function which is the fundamental defect in the development of NIDDM, hypertension and cardiovascular diseases. Objective: To assess the secretory status of insulin in adult obese female. Methods: The present study was a cross sectional analytical study and conducted in the Department of Physiology, Dhaka Medical College, Dhaka from July 2012 to June 2013. 50 obese female subjects of 20-40 years were included from Out-patient Department (Obesity clinic) of BIRDEM Hospital, Dhaka and by personal contact from different areas of Dhaka city. 50 age matched, healthy non-obese female subjects selected as controls . Fasting serum insulin level was measured by ELISA and fasting glucose level was measured by Glucose oxidase method. The insulin secretory status was calculated by HOMA-%B using HOMA software. For statistical analysis unpaired Student’s ‘t’ test and Pearson’s correlation coefficient (r) test were performed as applicable . Result: Mean fasting serum insulin and HOMA%B (P<0.001) were higher in the obese than that non obese. Fasting serum insulin level and HOMA%B showed significantly positive correlation with WHR. Conclusion: This study concludes that obese individual develops a state of insulin hypersecretion and hyperinsulinemia.
ABSTRACT
Background: Aging is associated with increased prevalence of thyroid function abnormalities including hypothyroidism. A meta-analysis showed an increased prevalence and incidence of cardiovascular mortality only in a relatively younger population. Objective: To compare the thyroid function status in IHD patients of different age groups. Methods: This cross sectional study was carried out on 31 IHD subjects aged 35-59 years (Group B1) and 19 IHD subjects aged 60-85 years (Group B2) in the Department of Physiology, Dhaka Medical College, Dhaka from July 2009 to June 2010. For comparison 24 healthy subjects aged 35-59 years (Group A1) and 26 with age 60-85 years (Group A2) were studied. The IHD subjects were selected from coronary care unit of cardiology department and OPD of Dhaka Medical College Hospital, Dhaka. Serum FT3, FT4 and TSH of all subjects were measured by radioimmunoassay. Statistical analysis was done by unpaired Student’s ‘t’ test. Results: The mean ± SD of FT3 and FT4 were significantly lower and TSH was significantly higher in Group B1 IHD patients than that of Group A1 healthy subjects, but no difference was found between Group A2 and Group B2 and between Group B1 and Group B2. Conclusion: Thyroid hormone levels are significantly lower in younger IHD population (age 35-59 years) than the age-matched normal controls.
ABSTRACT
Background: Thyroid dysfunction especially hypothyroidism is cardiovascular risk factor because of its association with elevated serum total and LDL cholesterol. Objective: To assess the association of thyroid hormone levels with IHD. Methods: This cross-sectional study was carried out on 50 IHD subjects aged 35 to 85 years (Group B), in the Department of Physiology, Dhaka Medical College, Dhaka from of July 2009 to June 2010. For comparison 50 age, sex, and BMI matched apparently healthy subjects (Group-A) were also studied. The study subjects were selected from coronary care unit (CCU) of Cardiology Department & OPD of Dhaka Medical College Hospital, Dhaka. Serum FT3, FT4 and TSH were assessed by radio-immuno assay. Statistical analysis was done by student’s unpaired ‘t’ test and chi-square test as applicable. Result: The mean ±SD of serum FT3 and FT4 were significantly lower and serum TSH was significantly higher in IHD patients than that of healthy subjects (p<0.05). Conclusion: Hypothyroidism occurs in patients suffering from IHD.