ABSTRACT
Purpose To study the clinical characteristics of disease development,pathology,treatment and prognosis in ovarian growing teratoma syndrome (GTS).Methods The clinical and pathological data of 1 cases of ovarian GTS were analyzed retrospectively,and the special course of disease and pathological changes were summarized.Results Ultrasound examination revealed a mass measuring 93 mm × 72 mm in the right ovary.Grossly,the tumor was cystic and solid,and solid area was mainly cauliflower like,with soft texture and small amount of hair and grease.Histopathological examination showed there were multifocal immature primitive neural tube in the solid area.Immunohistochemical staining showed the tumor cell were positive for NSE and focal positive for Syn,S-100,CD99,and CD56.In the preoperation,AFP and CA125 were 48.7 ng/mL and 84.2 U/mL.The right ovary mass and uterus,bilateral appendages,omentum and appendix were resected by radical operation,and two courses of chemotherapy postoperative were given.After 17 months,a solid peritoneal mass mesauring 47mm ×35mm × 24mm,was found in the original position by gynecological ultrasound.Grossly,it was solid and soft with some bone tissue.Histopathological examination showed a few immature cartilage and mesenchymal tissue.Tumor markers were within the normal range,the peritoneal mass and bilateral pelvic lymph nodes were excised thoroughly.A slight elevated in CA125 one month after surgery.After successive five courses of chemotherapy,no tumor recurred for 19 months follow up.Conclusion The diagnosis of GTS requires a combination of the overall course of the disease.The pathologic diagnosis of mature teratoma on postoperative recurred tumor are important indications for the differential diagnosis of GTS.Therefore,the tumor markers and abdominal and pelvic ultrasonography should be checked regularly,and reasonable treatment should be carried out aceording to the individual condition of the patient to avoid unnecessary chemotherapy.Keeping the fertility of young patients and preventing postoperative complications is the key to ensure a good prognosis.
ABSTRACT
Objective To study the clinicopathological characteristics ,diagnosis,differential diagnosis,therapy and prognosis of glomus tumor.Methods The clinical and histopathological features and immunohistochemical phenotypes were retrospectively analyzed in 10 cases of glomus tumors,with review of the related literature.Results Of 10 patients,6 cases were female,4 cases were male,mean age 45.3 years old.Glomus tumors commonly occurred in the end of fingers .We found that the shape of tumor was round or ovoid ,and the tumor exhibited grey red.The size of these tumors ranged from 0.4 cm to 2.7 cm in diameter.Microscopically,The tumor cells were uniform-sized,round or o-val,with clear or eosinophilic cytoplasm .The atypia and mitotic activity of these tumors were not observed .The tumor cells arranged around the thin-walled blood vessels showing a hemangiopericytoma-like pattern .Myxoid change was seen in the stroma of glomus tumor .The tumor cells expressed Vimentin ,SMA and collagen Ⅳby immunohistochemical staining ,but negative for CgA ,Syn,desmin,CD34,CK and S-100. All 10 cases were benign,and had no evidence of the recurrence in follow-up for 14 to 145 months.Conclusion Glomus tumor is a very rare soft tissue tumor ,and the atypical morphology of glomus tumors in unusual location may cause diagnostic difficulty .The diagnosis for glomus tumor depends mainly on histopathological features and immunohistochemical markers .