ABSTRACT
Objective To investigate whether serum Lp(a) level was related to the different genotypes of hepatitis C virus.Methods The serum and corresponding clinical data of 105 patients (male:59,female:46;average age:43.4± 19.8) infected HCV and 30 healthy controls in the Second Affiliated Hospital of Xi'an Jiaotong University from June 2016 to June 2017 were collected.HCV genotypes was detected by PCR-reverse point hybridization,all Lp(a) levels of serum were detected by using automatic biochemical analyzer AU5800 of Beckman.The comparison of the mean of the two samples was applied with t-test,analysis of variance was applied to compare among samples.Results There were 5 genotypes found in 105 patients,including 31 patients with genotype 1b of HCV infection,30 patients with genotype 2a infection,19 patients with genotype 3a infection,12 patients with genotype 3b infection,13 patients with genotype 6a infection.The serum levels of Lp(a) in patients infected with HCV (10.87±6.21 mg/L) were significantly lower than that of healthy controls (21.51± 12.99 mg/L),the difference was statistically significant (t =6.281,P＜0.000 1),meanwhile,the level of each genotype (3 b,6a,2a,3a and 1b was 12.51±6.11,9.75±5.73,12.28±7.63,9.22±4.47 和 10.37±5.75 mg/L,respectively) was lower than that of healthy controls,respectively (t =4.355,3.356,3.965,2.288 and 3.119,all P＜ 0.05),and the difference among genotypes was no statistically significant (F=1.091,P=0.365 4).Conclusion Compared with healthy controls,HCV could reduce the expression of serum Lp(a),but the serum Lp(a) levels were not associated with the genotypes of HCV.
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Objective To explore effects of seasonal variation on blood lead in children.Methods Anodic stripping voltammetry(ASV) was used to detect blood lead level in children.The enrolled children were divided into 4 groups as follows:young children(ages 1 month to 3 years);preschool(ages 3 to 6 years);school(ages 6 to 12 years);teenagers(ages 12 to 18 years),and children′s blood lead level and lead poisoning rates were analyzed in the light of seasonality.Results Total 13 233 children were observed,aged from 1 month to 18 years old,8315 males,4918 females.The average blood lead levels were 60 ?g/L,the 5~(th) and 95~(th) percentage was 19,138 ?g/L.The rate of lead poisoning in children was 14.8%,with the majority of low-grade(?~2=116.3125 P
ABSTRACT
Objective To explore the relationship between detective time for serum cardiac troponin I(cTnI) and their positive rate in diagnosis of viral myocarditis(VM).Methods Twenty-one cases of VM were designed as the test group.The serum cTnI were dynamically detected and compared with the normal control group.Results The serum cTnI were all negative in the normal control group,of 6 cases(28.6%) in the test group were positive when admission,of 7 cases(33.3%),8 cases(38.1%),9 cases(42.9%),13 cases(61.9%) and 4 cases(19%) were positive 6,12,18,24,48,72 h and 10 to 14 days laters respectively.There were statistic significances,compared the accumulative total positive rate of 48 h and 72 h after hospitalization with of emission and of 10 to 14 days after hospitalization,respectively.Conclusion Monitoring serum cTnI dynamically may increase the positive rate of cTnI for the suspected patients.