ABSTRACT
When eukaryotic cells face various environment stimulation,eukaryotic cells form some dense granules in hyalomitome,that are stress granules(SGs).They have antioxidant and inhibit apoptosis. Interaction between mRNA-binding proteins promotes stress granule formation. Assembly and disassembly of stress granules are modulated by va-rious post-translational modifications as well as numerous ATP-dependent RNP or protein remodeling complexes.Stress granules have the ability of liquidity,and energy input is required to maintain their dynamic state.Stress granule for-mation can regulate the process of stress reaction,virus infection and the signal transduction.The formation of constant and the abnormal stress granules result in neurodegenerative diseases and certain types of cancer.
ABSTRACT
When eukaryotic cells face various environment stimulation,eukaryotic cells form some dense granules in hyalomitome,that are stress granules(SGs).They have antioxidant and inhibit apoptosis. Interaction between mRNA-binding proteins promotes stress granule formation. Assembly and disassembly of stress granules are modulated by va-rious post-translational modifications as well as numerous ATP-dependent RNP or protein remodeling complexes.Stress granules have the ability of liquidity,and energy input is required to maintain their dynamic state.Stress granule for-mation can regulate the process of stress reaction,virus infection and the signal transduction.The formation of constant and the abnormal stress granules result in neurodegenerative diseases and certain types of cancer.