ABSTRACT
Objective To investigate the effects of different bolus and swallow patterns on esophageal manometry in patients with gastroesophageal reflux disease by high resolution manometry .Methods Patients with gastroesophageal reflux disease questionnaire score of more than 8 points and positive 24-hour pH monitoring were included in the study .All the patients were detected by liquid swallow ,solid swallow and continuous swallow .The parameters and comprehensive diagnosis were in accordance with the Chicago Standard .Results A total of 42 patients with gastroesophageal reflux disease were enrolled . Compared with the dynamic parameters of liquid swallow ,the residual pressure of upper esophageal sphincter [(11 .07 ± 3 .97 ,5 .29 ± 3 .36)mmHg] decreased ,the distal latency [(6 .28 ± 1 .87 ,8 .98 ± 2 .25)s] ,and lower esophageal sphincter relaxation time [(7 .79 ± 0 .98 ,10 .69 ± 13 .04)s] prolonged significantly (all P<0 .05) .In the comprehensive diagnosis of esophageal motility ,compared with liquid swallow (38 .1% ) , continuous liquid swallow showed a more sensitive positive diagnostic rate of ineffective esophageal motility (IEM) (63 .2% ) ,with a significant difference (P=0 .008) .Compared with that of liquid swallow ,the diagnostic rate (45 .2% ) of IEM by the solid swallow did not differ significantly (P=0 .581) . Among the ineffective contraction ,the rate of failed contraction (44.3% ) of solid swallow was higher than that of liquid swallow (22 .6% ) .Conclusion Solid swallow is more likely to induce severe esophageal hypomotility disorders than liquid swallow.Continuous swallow has more sensitivity in the diagnosis of IEM.Therefore.it can be used as a supplement to routine manometry in patients with eastroesophageal reflux disease.
ABSTRACT
Aim To summarize the 2015 version of the prescrip-tion preparations containing Schisandra chinensis in "Chinese Pharmacopoeia",and discover meaningful compatibility law of Schisandra chinensis. Methods The statistics of prescription preparations relating to Schisandra chinensis in 2015 edition of "Chinese Pharmacopoeia" were gathered to find the frequency of each herbal medicine,efficacy,medicine category,and dosage. A database was constructed and frequency statistics were coun-ted,the dendrogram was built by cluster analysis to get compati-bility law of herbal medicines,and then some modern research analysis was conducted. Results A total 100 kinds of prescrip-tion preparations were included,including 128 Chinese medi-cines,and the total using frequency was 906 times. A sum of 17 types of traditional Chinese medicine were used in this study, and most commonly used herbals were Qi-invigorating herbs(fre-quency 150,0. 1656),antipyretic(frequency 115,0. 1269), yin-nourishing herbs(frequency 91,0. 1004),Yang-invigorat-ing herbs(frequency 78,0. 8610),Hematinic(frequency 78, 0. 8610)and so on. The herb medicine of using frequency ranking the first 20 was Prepared Radix Rehmanniae(47),Ra-dix Ophiopogonis (39 ), tuckahoe (38 ), Membranous Milkvetch(36),Ural Licorice (35),ginseng (32),angelica (23),salvia miltiorrhiza(23),wolfberry fruit(21),respective-ly;cluster analysis showed that the traditional Chinese medicine with frequency more than 10 times could be divided into five cat-egories,while Radix Rehmanniae was classified as a separate class. Conclusions The main therapeutic theory about Schisan-dra is astringency,replenishing and promoting production of body fluid and tonifying the kidney to relieve mental strain in 2015 edition of "Chinese Pharmacopoeia". The prescription compatibility can be used for rational medicine Schisandra com-patibility,guiding rational administration for Schisandra chinen-sis,in-depth research and development of modern prescription provide reference.